UniProt Protein Function: | RAMP1: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Belongs to the RAMP family. |
UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, integral Chromosomal Location of Human Ortholog: 2q36-q37.1 Cellular Component: extracellular space; cell surface; integral to plasma membrane; plasma membrane; receptor complex Molecular Function:protein binding; calcitonin receptor binding; coreceptor activity; receptor activity; protein transporter activity; calcitonin receptor activity Biological Process: intracellular protein transport; G-protein coupled receptor protein signaling pathway; protein transport; positive regulation of protein amino acid glycosylation; receptor internalization; calcium ion transport; positive regulation of cAMP biosynthetic process; angiogenesis; regulation of G-protein coupled receptor protein signaling pathway |
NCBI Summary: | The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. [provided by RefSeq, Jul 2008] |
UniProt Code: | O60894 |
NCBI GenInfo Identifier: | 11134419 |
NCBI Gene ID: | 10267 |
NCBI Accession: | O60894.1 |
UniProt Secondary Accession: | O60894,Q6FGS5, |
UniProt Related Accession: | O60894 |
Molecular Weight: | 148 |
NCBI Full Name: | Receptor activity-modifying protein 1 |
NCBI Synonym Full Names: | receptor (G protein-coupled) activity modifying protein 1 |
NCBI Official Symbol: | RAMP1 |
NCBI Protein Information: | receptor activity-modifying protein 1; CRLR activity-modifying protein 1; receptor activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1 |
UniProt Protein Name: | Receptor activity-modifying protein 1 |
UniProt Synonym Protein Names: | Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1 |
Protein Family: | Receptor activity-modifying protein |
UniProt Gene Name: | RAMP1 |
UniProt Entry Name: | RAMP1_HUMAN |