RAD54L2 Antibody (PACO14951)
- SKU:
- PACO14951
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RAD54L2 Antibody (PACO14951) |
抗体コード: | PACO14951 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human RAD54L2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO14951(RAD54L2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14951(RAD54L2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | Adrenergic receptors (ARs) include four general types (a1, a2, b1 and b2) that are found in different target tissues and differ in their affinities and responses to various agonists and antagonists. The coupling of ARs to specific intracellular effectors is mediated through diverse heterotrimeric G proteins. ARs play a critical role in the development of prostate cancer, and transcriptional activity of AR is partly regulated by coregulatory proteins. RAD54L2 (RAD54-like 2), also known as ARIP4 (androgen receptor-interacting protein 4), HSPC325 or SRISNF2L, is a 1,467 amino acid, nuclear protein belonging to the SNF2/RAD54 helicase family that consists of one helicase ATP-binding domain and a helicase C-terminal domain. RAD54L2 is a DNA helicase that regulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. RAD54L2 is post-translationally sumoylated or phosphorylated upon DNA damage. |
シノニム: | RAD54-like 2 (S. cerevisiae) |
UniProt Protein Function: | RAD54L2: DNA helicase that modulates androgen receptor (AR)- dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro. Belongs to the SNF2/RAD54 helicase family. |
UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor; EC 3.6.4.12; Nuclear receptor co-regulator; Helicase Chromosomal Location of Human Ortholog: 3p21.2 Cellular Component: nucleus Molecular Function:DNA binding; transcription cofactor activity; protein kinase binding; helicase activity; ATP binding Biological Process: metabolic process |
UniProt Code: | Q9Y4B4 |
NCBI GenInfo Identifier: | 296439458 |
NCBI Gene ID: | 23132 |
NCBI Accession: | Q9Y4B4.4 |
UniProt Secondary Accession: | Q9Y4B4,Q8TB57, Q9BV54, |
UniProt Related Accession: | Q9Y4B4 |
Molecular Weight: | 1467 |
NCBI Full Name: | Helicase ARIP4 |
NCBI Synonym Full Names: | RAD54-like 2 (S. cerevisiae) |
NCBI Official Symbol: | RAD54L2 |
NCBI Official Synonym Symbols: | ARIP4; HSPC325; SRISNF2L |
NCBI Protein Information: | helicase ARIP4; RAD54-like protein 2; androgen receptor-interacting protein 4 |
UniProt Protein Name: | Helicase ARIP4 |
UniProt Synonym Protein Names: | Androgen receptor-interacting protein 4; RAD54-like protein 2 |
Protein Family: | Helicase |
UniProt Gene Name: | RAD54L2 |
UniProt Entry Name: | ARIP4_HUMAN |