RAD23A Antibody (PACO31748)
- SKU:
- PACO31748
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RAD23A Antibody (PACO31748) |
抗体コード: | PACO31748 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human UV excision repair protein RAD23 homolog A protein (2-201AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot All lanes: RAD23A antibody at 3µg/ml Lane 1: MCF-7 whole cell lysate Lane 2: Hela whole cell lysate Lane 3: Raji whole cell lysate Lane 4: Jurkat whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 40, 34 kDa Observed band size: 34 kDa . |
![]() | Immunohistochemistry of paraffin-embedded human lung tissue using PACO31748 at dilution of 1:100. |
バックグラウンド: | Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC. (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome. |
シノニム: | UV excision repair protein RAD23 homolog A (HR23A) (hHR23A), RAD23A |
UniProt Protein Function: | RAD23A: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Belongs to the RAD23 family. |
UniProt Protein Details: | Protein type:DNA-binding; DNA repair, damage Chromosomal Location of Human Ortholog: 19p13.2 Molecular Function:polyubiquitin binding; protein binding; single-stranded DNA binding Biological Process: nucleotide-excision repair; positive regulation of viral genome replication; regulation of proteasomal ubiquitin-dependent protein catabolic process |
NCBI Summary: | The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012] |
UniProt Code: | P54725 |
NCBI GenInfo Identifier: | 1709983 |
NCBI Gene ID: | 5886 |
NCBI Accession: | P54725.1 |
UniProt Secondary Accession: | P54725,Q59EU8, Q5M7Z1, K7ESE3, |
UniProt Related Accession: | P54725 |
Molecular Weight: | 39,538 Da |
NCBI Full Name: | UV excision repair protein RAD23 homolog A |
NCBI Synonym Full Names: | RAD23 homolog A, nucleotide excision repair protein |
NCBI Official Symbol: | RAD23A |
NCBI Official Synonym Symbols: | HR23A; HHR23A |
NCBI Protein Information: | UV excision repair protein RAD23 homolog A |
UniProt Protein Name: | UV excision repair protein RAD23 homolog A |
Protein Family: | UV excision repair protein |
UniProt Gene Name: | RAD23A |
UniProt Entry Name: | RD23A_HUMAN |
Antibodies |
Anti-Rad23A Antibody (CAB3188) |
Anti-Rad23A Antibody (CAB19884)[KO Validated] |
Anti-Rad23A Antibody (CAB5147) |
RAD23A Antibody (PACO04865) |
RAD23A Antibody (PACO11692) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-HRP-conjugated Beta Actin Antibody (CABC028) |