RAD18 Antibody, HRP conjugated (PACO42239)
- SKU:
- PACO42239
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | RAD18 Antibody, HRP conjugated (PACO42239) |
抗体コード: | PACO42239 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human E3 ubiquitin-protein ligase RAD18 protein (1-495AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. Has ssDNA binding activity. |
シノニム: | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18), RAD18, RNF73 |
UniProt Protein Function: | RAD18: a structural maintenance of chromosomes (SMC) protein involved in postreplication repair of UV-damaged DNA. Has ssDNA binding activity. Interacts with Rad6 through a conserved ring-finger motif. Rad6 is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. |
UniProt Protein Details: | Protein type:DNA repair, damage; EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: XY body; replication fork; nucleus; chromatin Molecular Function:Y-form DNA binding; protein binding; zinc ion binding; ubiquitin protein ligase binding; damaged DNA binding; polyubiquitin binding; ligase activity Biological Process: negative regulation of DNA recombination; protein ubiquitination; spermatogenesis; DNA repair; response to UV |
NCBI Summary: | The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NS91 |
NCBI GenInfo Identifier: | 313104165 |
NCBI Gene ID: | 56852 |
NCBI Accession: | Q9NS91.2 |
UniProt Secondary Accession: | Q9NS91,Q58F55, Q9NRT6, |
UniProt Related Accession: | Q9NS91 |
Molecular Weight: | 495 |
NCBI Full Name: | E3 ubiquitin-protein ligase RAD18 |
NCBI Synonym Full Names: | RAD18 E3 ubiquitin protein ligase |
NCBI Official Symbol: | RAD18 |
NCBI Official Synonym Symbols: | RNF73 |
NCBI Protein Information: | E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; RAD18 homolog; RING finger protein 73; RAD18, S. cerevisiae, homolog; postreplication repair protein RAD18; postreplication repair protein hRAD18p |
UniProt Protein Name: | E3 ubiquitin-protein ligase RAD18 |
UniProt Synonym Protein Names: | Postreplication repair protein RAD18; hHR18; hRAD18; RING finger protein 73 |
Protein Family: | E3 ubiquitin-protein ligase |
UniProt Gene Name: | RAD18 |
UniProt Entry Name: | RAD18_HUMAN |