RAB23 Antibody (PACO44791)
- SKU:
- PACO44791
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RAB23 Antibody (PACO44791) |
抗体コード: | PACO44791 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Recombinant Human Ras-related protein Rab-23 protein (1-237AA) |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: RAB23 antibody at 3.88µg/ml. Lane 1: Mouse ocular tissue. Lane 2: Rat brain tissue. Lane 3: Mouse kidney tissue. Lane 4: Mouse lung tissue. Lane 5: Mouse brain tissue. Lane 6: NIH/3T3 whole cell lysate. Lane 7: MCF-7 whole cell lysate. Lane 8: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 27 kDa. Observed band size: 27 kDa.. | |
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO44791 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human liver cancer using PACO44791 at dilution of 1:100. |
バックグラウンド: | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. |
シノニム: | Ras-related protein Rab-23, RAB23 |
UniProt Protein Function: | RAB23: Defects in RAB23 are the cause of acrocephalopolysyndactyly type 2 (ACPS2). A syndrome characterized by craniosynostosis, polysyndactyly, obesity, and cardiac defects. Belongs to the small GTPase superfamily. Rab family. |
UniProt Protein Details: | Protein type:G protein, monomeric; G protein, monomeric, Rab; G protein Chromosomal Location of Human Ortholog: 6p11 Cellular Component: phagocytic vesicle membrane; cytoplasm; plasma membrane; endosome membrane; autophagic vacuole; phagocytic vesicle Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding Biological Process: negative regulation of proteolysis; protein transport; spinal cord dorsal/ventral patterning; cellular defense response; cilium biogenesis; embryonic digit morphogenesis; Rab protein signal transduction; negative regulation of transcription factor import into nucleus; autophagic vacuole formation; regulation of smoothened signaling pathway Disease: Carpenter Syndrome 1 |
NCBI Summary: | This gene encodes a small GTPase of the Ras superfamily. Rab proteins are involved in the regulation of diverse cellular functions associated with intracellular membrane trafficking, including autophagy and immune response to bacterial infection. The encoded protein may play a role in central nervous system development by antagonizing sonic hedgehog signaling. Disruption of this gene has been implicated in Carpenter syndrome as well as cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
UniProt Code: | Q9ULC3 |
NCBI GenInfo Identifier: | 523425714 |
NCBI Gene ID: | 51715 |
NCBI Accession: | NP_001265595.1 |
UniProt Secondary Accession: | Q9ULC3,Q68DJ6, Q8NI06, Q9P023, B2R9I5, |
UniProt Related Accession: | Q9ULC3 |
Molecular Weight: | 26,659 Da |
NCBI Full Name: | ras-related protein Rab-23 |
NCBI Synonym Full Names: | RAB23, member RAS oncogene family |
NCBI Official Symbol: | RAB23 |
NCBI Official Synonym Symbols: | HSPC137 |
NCBI Protein Information: | ras-related protein Rab-23; RAB family small GTP binding protein RAB 23 |
UniProt Protein Name: | Ras-related protein Rab-23 |
Protein Family: | Ras-related protein |
UniProt Gene Name: | RAB23 |
UniProt Entry Name: | RAB23_HUMAN |