RAB11B Antibody (PACO35422)
- SKU:
- PACO35422
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | RAB11B Antibody (PACO35422) |
抗体コード: | PACO35422 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human, Rat |
免疫原: | Recombinant Human Ras-related protein Rab-11B protein (2-215AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: RAB11B antibody at 2µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Rat gonadal tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 25, 20 kDa. Observed band size: 25 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO35422 at dilution of 1:100. |
バックグラウンド: | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acid, sis. |
シノニム: | Ras-related protein Rab-11B (GTP-binding protein YPT3), RAB11B, YPT3 |
UniProt Protein Function: | RAB11B: GTPase that modulates endosomal trafficking. Acts as a major regulator of membrane delivery during cytokinesis. Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Belongs to the small GTPase superfamily. Rab family. |
UniProt Protein Details: | Protein type:G protein, monomeric, Rab; G protein, monomeric; G protein Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: synaptic vesicle; recycling endosome; phagocytic vesicle membrane; synaptic vesicle membrane; mitochondrion; recycling endosome membrane; phagocytic vesicle; cell junction Molecular Function:GTPase activity; protein binding; GDP binding; GTP binding; myosin V binding Biological Process: receptor recycling; intracellular protein transport; regulated secretory pathway; constitutive secretory pathway; transferrin transport; Rab protein signal transduction; melanosome transport |
NCBI Summary: | The Ras superfamily of small GTP-binding proteins, which includes the Ras (see MIM 190020), Ral (see MIM 179550), Rho (see MIM 165390), Rap (see MIM 179520), and Rab (see MIM 179508) families, is involved in controlling a diverse set of essential cellular functions. The Rab family, including RAB11B, appears to play a critical role in regulating exocytotic and endocytotic pathways (summary by Zhu et al., 1994 [PubMed 7811277]).[supplied by OMIM, Nov 2010] |
UniProt Code: | Q15907 |
NCBI GenInfo Identifier: | 38258938 |
NCBI Gene ID: | 9230 |
NCBI Accession: | Q15907.4 |
UniProt Secondary Accession: | Q15907,Q2YDT2, Q5U0I1, Q6FHR0, Q6FI42, Q8NI07, A5YM50 B2R7I4, B4DMK0, D6W671, |
UniProt Related Accession: | Q15907 |
Molecular Weight: | 218 |
NCBI Full Name: | Ras-related protein Rab-11B |
NCBI Synonym Full Names: | RAB11B, member RAS oncogene family |
NCBI Official Symbol: | RAB11B |
NCBI Official Synonym Symbols: | H-YPT3 |
NCBI Protein Information: | ras-related protein Rab-11B; GTP-binding protein YPT3; RAB11B, member of RAS oncogene family |
UniProt Protein Name: | Ras-related protein Rab-11B |
UniProt Synonym Protein Names: | GTP-binding protein YPT3 |
Protein Family: | Ras-related protein |
UniProt Gene Name: | RAB11B |
UniProt Entry Name: | RB11B_HUMAN |