UniProt Protein Function: | QTRT1: Interacts with QTRTD1 to form an active queuine tRNA- ribosyltransferase. This enzyme exchanges queuine for the guanine at the wobble position of tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), thereby forming the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine). Belongs to the queuine tRNA-ribosyltransferase family.Protein type: Mitochondrial; RNA processing; EC 2.4.2.29; TransferaseChromosomal Location of Human Ortholog: 19p13.3Cellular Component: cytoplasm; mitochondrial outer membraneMolecular Function: queuine tRNA-ribosyltransferase activityBiological Process: queuosine biosynthetic process; tRNA modification |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuosine, which is found in tRNAs that code for asparagine, aspartic acid, histidine and tyrosine. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, Feb 2012] |
UniProt Code: | Q9BXR0 |
NCBI GenInfo Identifier: | 239938842 |
NCBI Gene ID: | 81890 |
NCBI Accession: | Q9BXR0.3 |
UniProt Secondary Accession: | Q9BXR0,Q96BQ4, Q9BXQ9, B4DFM7 |
UniProt Related Accession: | Q9BXR0 |
Molecular Weight: | 24,015 Da |
NCBI Full Name: | Queuine tRNA-ribosyltransferase |
NCBI Synonym Full Names: | queuine tRNA-ribosyltransferase catalytic subunit 1 |
NCBI Official Symbol: | QTRT1 |
NCBI Official Synonym Symbols: | TGT; TGUT; FP3235 |
NCBI Protein Information: | queuine tRNA-ribosyltransferase |
UniProt Protein Name: | Queuine tRNA-ribosyltransferase |
UniProt Synonym Protein Names: | Guanine insertion enzyme; tRNA-guanine transglycosylase |
Protein Family: | Queuine tRNA-ribosyltransferase |
UniProt Gene Name: | QTRT1 |
UniProt Entry Name: | TGT_HUMAN |