UniProt Protein Function: | Slob: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity. Belongs to the protein kinase superfamily. 7 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; Other group; Slob family Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: cytoplasm; plasma membrane; microtubule organizing center; nucleus Molecular Function:protein C-terminus binding; nucleotide binding; actin binding; ATP binding; phosphoinositide binding; protein kinase activity Biological Process: regulation of synaptic transmission; inflammatory response; protein amino acid phosphorylation; negative regulation of ion transport; negative regulation of ATPase activity |
NCBI Summary: | PXK binds to the Na,K-ATPase beta-1 (ATP1B1; MIM 182330) and beta-3 (ATP1B3; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 [PubMed 16135750]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q7Z7A4 |
NCBI GenInfo Identifier: | 31543452 |
NCBI Gene ID: | 54899 |
NCBI Accession: | NP_060241.2 |
UniProt Secondary Accession: | Q7Z7A4,Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3 Q6PK17, Q6ZN39, Q96CA3, Q96R07, Q9NXB8, |
UniProt Related Accession: | Q7Z7A4 |
Molecular Weight: | 64,950 Da |
NCBI Full Name: | PX domain-containing protein kinase-like protein |
NCBI Synonym Full Names: | PX domain containing serine/threonine kinase |
NCBI Official Symbol: | PXK |
NCBI Official Synonym Symbols: | MONaKA |
NCBI Protein Information: | PX domain-containing protein kinase-like protein; PX ser/thr kinase v2; PX serine/threonine kinase; modulator of Na,K-ATPase long form |
UniProt Protein Name: | PX domain-containing protein kinase-like protein |
UniProt Synonym Protein Names: | Modulator of Na,K-ATPase |
Protein Family: | PX domain-containing protein kinase-like protein |
UniProt Gene Name: | PXK |
UniProt Entry Name: | PXK_HUMAN |