PVRL3 Antibody (PACO16773)
- SKU:
- PACO16773
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PVRL3 Antibody (PACO16773) |
抗体コード: | PACO16773 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human PVRL3 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16773(PVRL3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16773(PVRL3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. |
シノニム: | poliovirus receptor-related 3 |
UniProt Protein Function: | PVRL3: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body. Belongs to the nectin family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 3q13 Cellular Component: cell-cell adherens junction; integral to plasma membrane; plasma membrane Molecular Function:cell adhesion molecule binding; protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion |
NCBI Summary: | This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q9NQS3 |
NCBI GenInfo Identifier: | 74762752 |
NCBI Gene ID: | 25945 |
NCBI Accession: | Q9NQS3.1 |
UniProt Secondary Accession: | Q9NQS3,Q6NVZ3, Q8NC05, Q8WVU4, Q9BVA9, Q9Y412, E9PFR0 |
UniProt Related Accession: | Q9NQS3 |
Molecular Weight: | 54,375 Da |
NCBI Full Name: | Nectin-3 |
NCBI Synonym Full Names: | nectin cell adhesion molecule 3 |
NCBI Official Symbol: | NECTIN3 |
NCBI Official Synonym Symbols: | PPR3; PRR3; CD113; PVRL3; PVRR3; CDW113; NECTIN-3 |
NCBI Protein Information: | nectin-3 |
UniProt Protein Name: | Nectin-3 |
UniProt Synonym Protein Names: | CDw113; Nectin cell adhesion molecule 3 |
UniProt Gene Name: | NECTIN3 |
UniProt Entry Name: | NECT3_HUMAN |
Antibodies |
Anti-PVRL3 Antibody (CAB4597) |
PVRL3 Antibody (PACO01149) |
PVRL3 Antibody (PACO01966) |
PVRL3 Antibody (PACO11615) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |