PVRL2 Antibody (PACO16770)
- SKU:
- PACO16770
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PVRL2 Antibody (PACO16770) |
抗体コード: | PACO16770 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
反応性: | Human |
免疫原: | Fusion protein of human PVRL2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16770(PVRL2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. |
シノニム: | poliovirus receptor-related 2 (herpesvirus entry mediator B) |
UniProt Protein Function: | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). |
NCBI Summary: | This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q92692 |
NCBI GenInfo Identifier: | 12643789 |
NCBI Gene ID: | 5819 |
NCBI Accession: | Q92692.1 |
UniProt Secondary Accession: | Q92692,O75455, Q6IBI6, Q96J29, A8K5L5, |
UniProt Related Accession: | Q92692 |
Molecular Weight: | |
NCBI Full Name: | Nectin-2 |
NCBI Synonym Full Names: | nectin cell adhesion molecule 2 |
NCBI Official Symbol: | NECTIN2 |
NCBI Official Synonym Symbols: | HVEB; PRR2; CD112; PVRL2; PVRR2 |
NCBI Protein Information: | nectin-2 |
UniProt Protein Name: | Nectin-2 |
UniProt Synonym Protein Names: | Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Poliovirus receptor-related protein 2; CD_antigen: CD112 |
UniProt Gene Name: | PVRL2 |
UniProt Entry Name: | PVRL2_HUMAN |
Antibodies |
Anti-Nectin 2/CD112 Antibody (CAB5378) |
Anti-Nectin 2/CD112 Antibody (CAB9622) |
PVRL2 Antibody (PACO06897) |
PVRL2 Antibody (PACO11614) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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