UniProt Protein Function: | PTP4A2: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Promotes tumors. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB. Belongs to the protein-tyrosine phosphatase family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p35 Cellular Component: cytoplasm; nucleus Molecular Function:prenylated protein tyrosine phosphatase activity |
NCBI Summary: | The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010] |
UniProt Code: | Q12974 |
NCBI GenInfo Identifier: | 68566159 |
NCBI Gene ID: | 8073 |
NCBI Accession: | Q12974.1 |
UniProt Secondary Accession: | Q12974,O00649, Q15197, Q15259, Q15260, Q15261, A8K9I8 B4DM39, D3DPP0, E9PGJ6, R4GN50, |
UniProt Related Accession: | Q12974 |
Molecular Weight: | 16,367 Da |
NCBI Full Name: | Protein tyrosine phosphatase type IVA 2 |
NCBI Synonym Full Names: | protein tyrosine phosphatase type IVA, member 2 |
NCBI Official Symbol: | PTP4A2 |
NCBI Official Synonym Symbols: | HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b |
NCBI Protein Information: | protein tyrosine phosphatase type IVA 2 |
UniProt Protein Name: | Protein tyrosine phosphatase type IVA 2 |
UniProt Synonym Protein Names: | HU-PP-1; OV-1; PTP(CAAXII); Protein-tyrosine phosphatase 4a2; Protein-tyrosine phosphatase of regenerating liver 2; PRL-2 |
Protein Family: | Protein tyrosine phosphatase |
UniProt Gene Name: | PTP4A2 |
UniProt Entry Name: | TP4A2_HUMAN |