PSPC1 Antibody (PACO60797)
- SKU:
- PACO60797
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PSPC1 Antibody (PACO60797) |
抗体コード: | PACO60797 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Paraspeckle component 1 protein (191-299AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
バックグラウンド: | Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. |
シノニム: | Paraspeckle component 1 (Paraspeckle protein 1), PSPC1, PSP1 |
UniProt Protein Function: | PSPC1: Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Together with NONO, required for the formation of nuclear paraspeckles. Belongs to the PSPC family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:RNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; nucleolus; nuclear speck; paraspeckles Molecular Function:protein binding; nucleotide binding Biological Process: transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm |
NCBI Summary: | This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011] |
UniProt Code: | Q8WXF1 |
NCBI GenInfo Identifier: | 109240550 |
NCBI Gene ID: | 55269 |
NCBI Accession: | NP_001035879.1 |
UniProt Secondary Accession: | Q8WXF1,Q5JTQ3, Q8NCZ9, Q8WXE8, Q9NV36, |
UniProt Related Accession: | Q8WXF1 |
Molecular Weight: | 58,744 Da |
NCBI Full Name: | paraspeckle component 1 |
NCBI Synonym Full Names: | paraspeckle component 1 |
NCBI Official Symbol: | PSPC1 |
NCBI Official Synonym Symbols: | PSP1 |
NCBI Protein Information: | paraspeckle component 1; paraspeckle protein 1 |
UniProt Protein Name: | Paraspeckle component 1 |
UniProt Synonym Protein Names: | Paraspeckle protein 1 |
Protein Family: | Paraspeckle component |
UniProt Gene Name: | PSPC1 |
UniProt Entry Name: | PSPC1_HUMAN |