PSMC5 Antibody (PACO51898)
- SKU:
- PACO51898
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | PSMC5 Antibody (PACO51898) |
抗体コード: | PACO51898 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IF |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:2000-1:10000, IF:1:50-1:500 |
反応性: | Human |
免疫原: | Recombinant Human 26S proteasome regulatory subunit 8 protein (253-324AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HepG2 whole cell lysate. All lanes: PSMC5 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 46, 45 kDa. Observed band size: 46 kDa.. |
![]() | Immunofluorescent analysis of PC-3 cells using PACO51898 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
バックグラウンド: | The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. |
シノニム: | 26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG), PSMC5, SUG1 |
UniProt Protein Function: | RPT6: The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. Belongs to the AAA ATPase family. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17q23.3 Cellular Component: nucleoplasm; proteasome complex; membrane; proteasome regulatory particle; cytoplasm; inclusion body; cytoplasmic vesicle; nucleus; cytosol Molecular Function:thyrotropin-releasing hormone receptor binding; protein binding; TATA-binding protein binding; ATPase activity; transcription cofactor activity; transcription factor binding; ATP binding Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; protein polyubiquitination; viral reproduction; apoptosis; positive regulation of transcription, DNA-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of apoptosis; antigen processing and presentation of peptide antigen via MHC class I; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of programmed cell death; antigen processing and presentation of exogenous peptide antigen via MHC class I; gene expression; mitotic cell cycle; regulation of amino acid metabolic process; negative regulation of transcription, DNA-dependent; G1/S transition of mitotic cell cycle; negative regulation of apoptosis |
NCBI Summary: | The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
UniProt Code: | P62195 |
NCBI GenInfo Identifier: | 49065819 |
NCBI Gene ID: | 5705 |
NCBI Accession: | P62195.1 |
UniProt Secondary Accession: | P62195,O35051, O43208, P47210, P52915, P52916, A8K3Z3 A8K763, |
UniProt Related Accession: | P62195 |
Molecular Weight: | 406 |
NCBI Full Name: | 26S protease regulatory subunit 8 |
NCBI Synonym Full Names: | proteasome (prosome, macropain) 26S subunit, ATPase, 5 |
NCBI Official Symbol: | PSMC5 |
NCBI Official Synonym Symbols: | S8; p45; SUG1; SUG-1; TBP10; TRIP1; p45/SUG |
NCBI Protein Information: | 26S protease regulatory subunit 8; MSUG1 protein; proteasome subunit p45; thyroid receptor interactor 1; Tat-binding protein homolog 10; proteasome 26S ATPase subunit 5; proteasome 26S subunit ATPase 5; 26S proteasome AAA-ATPase subunit RPT6; thyroid horm |
UniProt Protein Name: | 26S protease regulatory subunit 8 |
UniProt Synonym Protein Names: | 26S proteasome AAA-ATPase subunit RPT6; Proteasome 26S subunit ATPase 5; Proteasome subunit p45; Thyroid hormone receptor-interacting protein 1; TRIP1; p45/SUG |
Protein Family: | 26S protease regulatory |
UniProt Gene Name: | PSMC5 |
UniProt Entry Name: | PRS8_HUMAN |