PROX1 Antibody (PACO56086)
- SKU:
- PACO56086
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
抗体名: | PROX1 Antibody (PACO56086) |
抗体コード: | PACO56086 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
反応性: | Human |
免疫原: | Recombinant Human Prospero homeobox protein 1 protein (262-477AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: HepG2 whole cell lysate. All lanes: PROX1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 84 kDa. Observed band size: 84 kDa. |
バックグラウンド: | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. |
シノニム: | Prospero homeobox protein 1 (Homeobox prospero-like protein PROX1) (PROX-1), PROX1 |
UniProt Protein Function: | PROX1: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons. Belongs to the Prospero homeobox family. |
UniProt Protein Details: | Protein type:DNA-binding; Transcription factor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1q41 Cellular Component: cytoplasm; nucleus Molecular Function:RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor binding; protein binding; DBD domain binding; DNA binding; LBD domain binding; transcription factor activity; transcription corepressor activity Biological Process: transcription from RNA polymerase II promoter; lens development in camera-type eye; circadian rhythm; neural tube development; positive regulation of cyclin-dependent protein kinase activity; ventricular cardiac myofibril development; muscle thin filament assembly; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; olfactory placode formation; negative regulation of cell proliferation; venous blood vessel morphogenesis; pancreas development; positive regulation of cell proliferation; lymphangiogenesis; ventricular cardiac muscle morphogenesis; kidney development; response to nutrient levels; dentate gyrus development; negative regulation of transcription factor activity; positive regulation of cell cycle; liver development; regulation of circadian rhythm; cerebellar granule cell differentiation; dorsal spinal cord development; negative regulation of viral genome replication; regulation of gene expression; otic placode formation; embryonic retina morphogenesis in camera-type eye; positive regulation of endothelial cell proliferation; optic placode formation involved in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; retina morphogenesis in camera-type eye; lung development |
NCBI Summary: | The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] |
UniProt Code: | Q92786 |
NCBI GenInfo Identifier: | 85702224 |
NCBI Gene ID: | 5629 |
NCBI Accession: | Q92786.2 |
UniProt Secondary Accession: | Q92786,Q5SW76, Q8TB91, A6NK29, A8K2B1, |
UniProt Related Accession: | Q92786 |
Molecular Weight: | 737 |
NCBI Full Name: | Prospero homeobox protein 1 |
NCBI Synonym Full Names: | prospero homeobox 1 |
NCBI Official Symbol: | PROX1 |
NCBI Protein Information: | prospero homeobox protein 1; prospero-related homeobox 1; homeobox prospero-like protein PROX1 |
UniProt Protein Name: | Prospero homeobox protein 1 |
UniProt Synonym Protein Names: | Homeobox prospero-like protein PROX1; PROX-1 |
Protein Family: | Prospero homeobox protein |
UniProt Gene Name: | PROX1 |
UniProt Entry Name: | PROX1_HUMAN |