PRLR Antibody, HRP conjugated (PACO51871)
- SKU:
- PACO51871
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | PRLR Antibody, HRP conjugated (PACO51871) |
抗体コード: | PACO51871 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Prolactin receptor protein (330-548AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. |
シノニム: | Prolactin receptor (PRL-R), PRLR |
UniProt Protein Function: | PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 5p13.2 Cellular Component: cell surface; plasma membrane Molecular Function:peptide hormone binding; protein binding Biological Process: embryo implantation; transmembrane receptor protein tyrosine kinase activation (dimerization) Disease: Hyperprolactinemia; Multiple Fibroadenomas Of The Breast |
NCBI Summary: | This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011] |
UniProt Code: | P16471 |
NCBI GenInfo Identifier: | 130321 |
NCBI Gene ID: | 5618 |
NCBI Accession: | P16471.1 |
UniProt Secondary Accession: | P16471,Q16354, Q8TD75, Q8TD78, Q96P35, Q96P36, Q9BX87 Q9UHJ5, B2R882, D1MDP1, |
UniProt Related Accession: | P16471 |
Molecular Weight: | 70kDa |
NCBI Full Name: | Prolactin receptor |
NCBI Synonym Full Names: | prolactin receptor |
NCBI Official Symbol: | PRLR |
NCBI Official Synonym Symbols: | HPRL; MFAB; hPRLrI |
NCBI Protein Information: | prolactin receptor |
UniProt Protein Name: | Prolactin receptor |
Protein Family: | Prolactin receptor |
UniProt Gene Name: | PRLR |