UniProt Protein Function: | PRKD3: a CAMK kinase of the PKD family. An important component of signaling pathways downstream from novel PKC enzymes after B-cell receptor engagement. Novel isoforms regulate human keratinocyte differentiation |
UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; EC 2.7.11.13; CAMK group; PKD family Chromosomal Location of Human Ortholog: 2p21 Cellular Component: cytoplasm; nucleoplasm Molecular Function:kinase activity; protein binding Biological Process: protein kinase C activation |
NCBI Summary: | This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015] |
UniProt Code: | O94806 |
NCBI GenInfo Identifier: | 12230239 |
NCBI Gene ID: | 23683 |
NCBI Accession: | O94806.1 |
UniProt Secondary Accession: | O94806,Q53TR7, Q8NEL8, D6W587, |
UniProt Related Accession: | O94806 |
Molecular Weight: | 68,123 Da |
NCBI Full Name: | Serine/threonine-protein kinase D3 |
NCBI Synonym Full Names: | protein kinase D3 |
NCBI Official Symbol: | PRKD3 |
NCBI Official Synonym Symbols: | EPK2; PKD3; PRKCN; PKC-NU; nPKC-NU |
NCBI Protein Information: | serine/threonine-protein kinase D3 |
UniProt Protein Name: | Serine/threonine-protein kinase D3 |
UniProt Synonym Protein Names: | Protein kinase C nu type; Protein kinase EPK2; nPKC-nu |
Protein Family: | Serine/threonine-protein kinase |
UniProt Gene Name: | PRKD3 |
UniProt Entry Name: | KPCD3_HUMAN |