PRKAR1B Antibody (PACO18829)
- SKU:
- PACO18829
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PRKAR1B Antibody (PACO18829) |
抗体コード: | PACO18829 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:50-1:200 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human PRKAR1B |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18829(PRKAR1B Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200). |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18829(PRKAR1B Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP. |
シノニム: | Protein kinase, cAMP-dependent, regulatory, type I, beta |
UniProt Protein Function: | PKAR1B: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The inactive holoenzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP releases the two active catalytic monomers and the regulatory dimer. Interacts with PRKX; regulates this cAMP-dependent protein kinase. Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. Belongs to the cAMP-dependent kinase regulatory chain family. |
UniProt Protein Details: | Protein type:Protein kinase, regulatory subunit Chromosomal Location of Human Ortholog: 7p22 Cellular Component: cytosol Molecular Function:cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity Biological Process: activation of protein kinase A; blood coagulation; renal water homeostasis |
NCBI Summary: | The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015] |
UniProt Code: | P31321 |
NCBI GenInfo Identifier: | 229463042 |
NCBI Gene ID: | 5575 |
NCBI Accession: | P31321.4 |
UniProt Secondary Accession: | P31321,Q8N422, |
UniProt Related Accession: | P31321 |
Molecular Weight: | 43,073 Da |
NCBI Full Name: | cAMP-dependent protein kinase type I-beta regulatory subunit |
NCBI Synonym Full Names: | protein kinase cAMP-dependent type I regulatory subunit beta |
NCBI Official Symbol: | PRKAR1B |
NCBI Official Synonym Symbols: | PRKAR1 |
NCBI Protein Information: | cAMP-dependent protein kinase type I-beta regulatory subunit |
UniProt Protein Name: | cAMP-dependent protein kinase type I-beta regulatory subunit |
Protein Family: | cAMP-dependent protein kinase |
UniProt Gene Name: | PRKAR1B |
UniProt Entry Name: | KAP1_HUMAN |
Antibodies | ELISA Kits |
Anti-PRKAR1B Antibody (CAB10125) | KAP1 Colorimetric Cell-Based ELISA |
PRKAR1B Antibody (PACO06758) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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