PREX2 Antibody, HRP conjugated (PACO47947)
- SKU:
- PACO47947
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | PREX2 Antibody, HRP conjugated (PACO47947) |
抗体コード: | PACO47947 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (1417-1592AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the β γ subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase. |
シノニム: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein (P-Rex2) (PtdIns(3,4,5)-dependent Rac exchanger 2) (DEP domain-containing protein 2), PREX2, DEPDC2 |
UniProt Protein Function: | PREX2: Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:GEFs; GEFs, Rac/Rho; Phosphatase, regulatory subunit Chromosomal Location of Human Ortholog: 8q13.2 Cellular Component: cytoplasm; plasma membrane Molecular Function:GTPase activator activity; Rac guanyl-nucleotide exchange factor activity Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of protein kinase activity; negative regulation of TOR signaling pathway |
NCBI Summary: | The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers. [provided by RefSeq, Apr 2016] |
UniProt Code: | Q70Z35 |
NCBI GenInfo Identifier: | 47578115 |
NCBI Gene ID: | 80243 |
NCBI Accession: | NP_079146.2 |
UniProt Secondary Accession: | Q70Z35,Q32KL0, Q32KL1, Q6R7Q3, Q6R7Q4, Q9H805, Q9H961 B4DFX0, |
UniProt Related Accession: | Q70Z35 |
Molecular Weight: | |
NCBI Full Name: | phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein isoform a |
NCBI Synonym Full Names: | phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 |
NCBI Official Symbol: | PREX2 |
NCBI Official Synonym Symbols: | DEP.2; DEPDC2; P-REX2; PPP1R129 |
NCBI Protein Information: | phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
UniProt Protein Name: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
UniProt Synonym Protein Names: | DEP domain-containing protein 2 |
Protein Family: | Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein |
UniProt Gene Name: | PREX2 |
UniProt Entry Name: | PREX2_HUMAN |