PRCP Antibody, Biotin conjugated (PACO56931)
- SKU:
- PACO56931
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | PRCP Antibody, Biotin conjugated (PACO56931) |
抗体コード: | PACO56931 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Lysosomal Pro-X carboxypeptidase protein (347-443AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Cleaves C-terminal amino acid, linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acid, c pH, but enzymatic activity is retained with some substrates at neutral pH. |
シノニム: | Lysosomal Pro-X carboxypeptidase (EC 3.4.16.2) (Angiotensinase C) (Lysosomal carboxypeptidase C) (Proline carboxypeptidase) (Prolylcarboxypeptidase) (PRCP), PRCP, PCP |
UniProt Protein Function: | PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family. |
UniProt Protein Details: | Protein type:EC 3.4.16.2; Protease Chromosomal Location of Human Ortholog: 11q14 Cellular Component: lysosome; plasma membrane Molecular Function:serine carboxypeptidase activity; protein binding Biological Process: plasma kallikrein-kinin cascade; negative regulation of systemic arterial blood pressure; regulation of blood vessel endothelial cell migration; glucose homeostasis; proteolysis; blood coagulation; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway |
NCBI Summary: | This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. A pseudogene of this gene has been identified on chromosome 2. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | P42785 |
NCBI GenInfo Identifier: | 1172047 |
NCBI Gene ID: | 5547 |
NCBI Accession: | P42785.1 |
UniProt Related Accession: | P42785 |
Molecular Weight: | |
NCBI Full Name: | Lysosomal Pro-X carboxypeptidase |
NCBI Synonym Full Names: | prolylcarboxypeptidase |
NCBI Official Symbol: | PRCP |
NCBI Official Synonym Symbols: | PCP; HUMPCP |
NCBI Protein Information: | lysosomal Pro-X carboxypeptidase |
UniProt Protein Name: | Lysosomal Pro-X carboxypeptidase |
UniProt Synonym Protein Names: | Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP |
Protein Family: | Paracaspase |
UniProt Gene Name: | PRCP |
UniProt Entry Name: | PCP_HUMAN |