PPP1R13B Antibody (PACO49262)
- SKU:
- PACO49262
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PPP1R13B Antibody (PACO49262) |
抗体コード: | PACO49262 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
反応性: | Human |
免疫原: | Recombinant Human Apoptosis-stimulating of p53 protein 1 protein (375-675AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human testis tissue using PACO49262 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human breast cancer using PACO49262 at dilution of 1:100. |
バックグラウンド: | Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. |
シノニム: | Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B), PPP1R13B, ASPP1 KIAA0771 |
UniProt Protein Function: | PPP1R13B: Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Belongs to the ASPP family. |
UniProt Protein Details: | Protein type:Apoptosis; Protein phosphatase, regulatory subunit; Tumor suppressor Chromosomal Location of Human Ortholog: 14q32.33 Cellular Component: cytoplasm; nucleoplasm; nucleus; plasma membrane Molecular Function:p53 binding; protein binding Biological Process: negative regulation of cell cycle; regulation of apoptosis |
NCBI Summary: | This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q96KQ4 |
NCBI GenInfo Identifier: | 296439434 |
NCBI Gene ID: | 23368 |
NCBI Accession: | Q96KQ4.3 |
UniProt Secondary Accession: | Q96KQ4,O94870, B2RMX5, |
UniProt Related Accession: | Q96KQ4 |
Molecular Weight: | 119,565 Da |
NCBI Full Name: | Apoptosis-stimulating of p53 protein 1 |
NCBI Synonym Full Names: | protein phosphatase 1 regulatory subunit 13B |
NCBI Official Symbol: | PPP1R13B |
NCBI Official Synonym Symbols: | p85; ASPP1; p53BP2-like |
NCBI Protein Information: | apoptosis-stimulating of p53 protein 1 |
UniProt Protein Name: | Apoptosis-stimulating of p53 protein 1 |
UniProt Synonym Protein Names: | Protein phosphatase 1 regulatory subunit 13B |
Protein Family: | Apoptosis-stimulating of p53 protein |
UniProt Gene Name: | PPP1R13B |
UniProt Entry Name: | ASPP1_HUMAN |