PPP1CA Antibody, HRP conjugated (PACO51835)
- SKU:
- PACO51835
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | PPP1CA Antibody, HRP conjugated (PACO51835) |
抗体コード: | PACO51835 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Serine/threonine-protein phosphatase PP1-α catalytic subunit protein (192-330AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. |
シノニム: | Serine/threonine-protein phosphatase PP1-α catalytic subunit (PP-1A) (EC 3.1.3.16), PPP1CA, PPP1A |
UniProt Protein Function: | PPP1CA: is a catalytic subunit of protein phosphatase 1 (PP1), aubiquitous cytosolic serine-threonine phosphatase. Composed of a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting (or regulatory) subunits: PPP1R12A and PPP1R12B mediate binding to myosin; PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen; and PPP1R15A and PPP1R15B mediate binding to EIF2S1. PP1 is essential for cell division, plays critical roles in many cellular processes including glycogen metabolism, muscle contractility and protein synthesis, and is involved in the regulation of ionic conductances and long-term synaptic plasticity. Inhibits the synthesis of proteins involved in synaptic plasticity. Binds to the transcription factor cyclic AMP-dependent response element binding (CREB) and dephosphorylates it. May regulate chromatin condensation through regulation of histone H3 phosphorylation. Differentially expressed in gastric cancer. May participate in the neurodegenerative progress in Alzheimer's disease. Down-regulated in lung squamous cell carcinoma. |
UniProt Protein Details: | Protein type:EC 3.1.3.16; Nucleolus; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: cell-cell adherens junction; cytoplasm; cytosol; nuclear chromosome, telomeric region; nucleoplasm; nucleus; plasma membrane Molecular Function:phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein binding Biological Process: circadian regulation of gene expression; dephosphorylation; entrainment of circadian clock by photoperiod; negative regulation of protein binding; protein amino acid dephosphorylation; regulation of circadian rhythm |
NCBI Summary: | The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P62136 |
NCBI GenInfo Identifier: | 49065811 |
NCBI Gene ID: | 5499 |
NCBI Accession: | P62136.1 |
UniProt Secondary Accession: | P62136,P08129, P20653, P22802, Q07161, A6NNR3, B2R908 |
UniProt Related Accession: | P62136 |
Molecular Weight: | Calculated MW: 32kDa/37kDa/38kDaObserved MW: 38kDa |
NCBI Full Name: | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
NCBI Synonym Full Names: | protein phosphatase 1 catalytic subunit alpha |
NCBI Official Symbol: | PPP1CA |
NCBI Official Synonym Symbols: | PP1A; PP-1A; PPP1A; PP1alpha |
NCBI Protein Information: | serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
UniProt Protein Name: | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
Protein Family: | Serine/threonine-protein phosphatase |
UniProt Gene Name: | PPP1CA |