POMK Antibody, HRP conjugated (PACO40571)
- SKU:
- PACO40571
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | POMK Antibody, HRP conjugated (PACO40571) |
抗体コード: | PACO40571 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Protein O-mannose kinase protein (44-350AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. |
シノニム: | Protein O-mannose kinase (POMK) (EC 2.7.1.183) (Protein kinase-like protein SgK196) (Sugen kinase 196), POMK, SGK196 |
UniProt Protein Function: | POMK: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. STKL subfamily. |
UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.1.183; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Membrane protein, integral; Protein kinase, Other; Other group; Other-Unique family Chromosomal Location of Human Ortholog: 8p11.21 Cellular Component: endoplasmic reticulum membrane; integral to membrane Molecular Function:ATP binding; carbohydrate kinase activity; phosphotransferase activity, alcohol group as acceptor; protein kinase activity Biological Process: brain development; carbohydrate phosphorylation; learning and/or memory; neuromuscular process; neuron migration; protein amino acid O-linked glycosylation; protein amino acid phosphorylation; sensory perception of pain Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 12; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 12 |
NCBI Summary: | This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] |
UniProt Code: | Q9H5K3 |
NCBI GenInfo Identifier: | 485836935 |
NCBI Gene ID: | 84197 |
NCBI Accession: | NP_001264900.1 |
UniProt Related Accession: | Q9H5K3 |
Molecular Weight: | 40,050 Da |
NCBI Full Name: | protein O-mannose kinase |
NCBI Synonym Full Names: | protein-O-mannose kinase |
NCBI Official Symbol: | POMK |
NCBI Official Synonym Symbols: | SGK196; MDDGA12; MDDGC12 |
NCBI Protein Information: | protein O-mannose kinase |
UniProt Protein Name: | Protein O-mannose kinase |
UniProt Synonym Protein Names: | Protein kinase-like protein SgK196; Sugen kinase 196 |
Protein Family: | Protein O-mannose kinase |
UniProt Gene Name: | POMK |
UniProt Entry Name: | SG196_HUMAN |