POGLUT1 Antibody, Biotin conjugated (PACO63974)
- SKU:
- PACO63974
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | POGLUT1 Antibody, Biotin conjugated (PACO63974) |
抗体コード: | PACO63974 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Protein O-glucosyltransferase 1 protein (132-392AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development. Notch glucosylation does not affect Notch ligand binding. Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). |
シノニム: | Protein O-glucosyltransferase 1 (EC 2.4.1) (CAP10-like 46 kDa protein) (hCLP46) (KTEL motif-containing protein 1) (Myelodysplastic syndromes relative protein) (O-glucosyltransferase Rumi homolog) (hRumi) (Protein O-xylosyltransferase POGLUT1) (EC 2.4.2.26), POGLUT1, C3orf9 CLP46 KTELC1 MDSRP |
UniProt Protein Function: | KTELC1: UDP-glucosyltransferase. Belongs to the glycosyltransferase 90 family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; EC 2.4.2.26 Chromosomal Location of Human Ortholog: 3q13.33 Cellular Component: endoplasmic reticulum lumen Molecular Function:glucosyltransferase activity; UDP-glucosyltransferase activity; UDP-xylosyltransferase activity Biological Process: glycolipid metabolic process; positive regulation of Notch signaling pathway; protein amino acid O-linked glycosylation Disease: Dowling-degos Disease 4 |
NCBI Summary: | This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
UniProt Code: | Q8NBL1 |
NCBI GenInfo Identifier: | 74730148 |
NCBI Gene ID: | 56983 |
NCBI Accession: | Q8NBL1.1 |
UniProt Secondary Accession: | Q8NBL1,Q53GJ4, Q8N2T1, B2RD13, |
UniProt Related Accession: | Q8NBL1 |
Molecular Weight: | 46,189 Da |
NCBI Full Name: | Protein O-glucosyltransferase 1 |
NCBI Synonym Full Names: | protein O-glucosyltransferase 1 |
NCBI Official Symbol: | POGLUT1 |
NCBI Official Synonym Symbols: | Rumi; CLP46; MDSRP; C3orf9; KTELC1; MDS010; hCLP46; KDELCL1 |
NCBI Protein Information: | protein O-glucosyltransferase 1 |
UniProt Protein Name: | Protein O-glucosyltransferase 1 |
UniProt Synonym Protein Names: | CAP10-like 46 kDa protein; hCLP46; KTEL motif-containing protein 1; Myelodysplastic syndromes relative protein; O-glucosyltransferase Rumi homolog; hRumi; Protein O-xylosyltransferase (EC:2.4.2.26) |
Protein Family: | Protein O-glucosyltransferase |
UniProt Gene Name: | POGLUT1 |
UniProt Entry Name: | PGLT1_HUMAN |