PNP Antibody, HRP conjugated (PACO34619)
- SKU:
- PACO34619
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Description
抗体名: | PNP Antibody, HRP conjugated (PACO34619) |
抗体コード: | PACO34619 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Purine nucleoside phosphorylase protein (1-289AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. |
シノニム: | Purine nucleoside phosphorylase (PNP) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase), PNP, NP |
UniProt Protein Function: | NP: a metabolic enzyme with purine-nucleoside phosphorylase activity. Defects are the cause of nucleoside phosphorylase deficiency (NP deficiency), with severe T-cell immunodeficiency with neurologic disorder in children. |
UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Transferase; EC 2.4.2.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Chromosomal Location of Human Ortholog: 14q13.1 Cellular Component: cytoplasm; cytosol; intracellular Molecular Function:drug binding; nucleoside binding; phosphate binding; purine binding; purine-nucleoside phosphorylase activity Biological Process: immune response; inosine catabolic process; nicotinamide riboside catabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; positive regulation of alpha-beta T cell differentiation; positive regulation of T cell proliferation; purine nucleotide catabolic process; purine salvage; response to drug Disease: Purine Nucleoside Phosphorylase Deficiency |
NCBI Summary: | This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Jul 2008] |
UniProt Code: | P00491 |
NCBI GenInfo Identifier: | 108935929 |
NCBI Gene ID: | 4860 |
NCBI Accession: | P00491.2 |
UniProt Secondary Accession: | P00491,Q15160, Q5PZ03, B2R8S5, D3DS00, |
UniProt Related Accession: | P00491 |
Molecular Weight: | 32,118 Da |
NCBI Full Name: | Purine nucleoside phosphorylase |
NCBI Synonym Full Names: | purine nucleoside phosphorylase |
NCBI Official Symbol: | PNP |
NCBI Official Synonym Symbols: | NP; PUNP; PRO1837 |
NCBI Protein Information: | purine nucleoside phosphorylase |
UniProt Protein Name: | Purine nucleoside phosphorylase |
UniProt Synonym Protein Names: | Inosine phosphorylase; Inosine-guanosine phosphorylase |
Protein Family: | Polyribonucleotide nucleotidyltransferase |
UniProt Gene Name: | PNP |
UniProt Entry Name: | PNPH_HUMAN |