PLXNB2 Antibody (PACO64027)
- SKU:
- PACO64027
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PLXNB2 Antibody (PACO64027) |
抗体コード: | PACO64027 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
反応性: | Human |
免疫原: | Recombinant Human Inhibitor of nuclear factor kappa-B kinase-interacting protein (1458-1673AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Antigen Affinity purified & Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: A549 whole cell lysate, 293 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate. All lanes: PLXNB2 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 206 kDa. Observed band size: 206 kDa. |
バックグラウンド: | Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity). |
シノニム: | Plexin-B2 (MM1), PLXNB2, KIAA0315 |
UniProt Protein Function: | PLXNB2: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). Belongs to the plexin family. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: cell surface; integral to plasma membrane; intracellular Molecular Function:protein binding; semaphorin receptor activity Biological Process: regulation of cell shape; regulation of protein amino acid phosphorylation; neuroblast proliferation; neural tube closure; positive regulation of axonogenesis; brain development |
NCBI Summary: | Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008] |
UniProt Code: | O15031 |
NCBI GenInfo Identifier: | 118341393 |
NCBI Gene ID: | 23654 |
NCBI Accession: | AAI27771.1 |
UniProt Secondary Accession: | O15031,Q7KZU3, Q9BSU7, A6QRH0, |
UniProt Related Accession: | O15031 |
Molecular Weight: | 205,127 Da |
NCBI Full Name: | PLXNB2 protein |
NCBI Synonym Full Names: | plexin B2 |
NCBI Official Symbol: | PLXNB2 |
NCBI Official Synonym Symbols: | MM1; PLEXB2; Nbla00445; dJ402G11.3 |
NCBI Protein Information: | plexin-B2 |
UniProt Protein Name: | Plexin-B2 |
UniProt Synonym Protein Names: | MM1 |
Protein Family: | Plexin |
UniProt Gene Name: | PLXNB2 |
UniProt Entry Name: | PLXB2_HUMAN |