PLEKHG6 Antibody (PACO16725)
- SKU:
- PACO16725
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PLEKHG6 Antibody (PACO16725) |
抗体コード: | PACO16725 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse |
免疫原: | Fusion protein of human PLEKHG6 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16725(PLEKHG6 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
![]() | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 293T cells, Primary antibody: PACO16725(PLEKHG6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16725(PLEKHG6 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
バックグラウンド: | PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. |
シノニム: | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 |
UniProt Protein Function: | PLEKHG6: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 12p13.31Molecular Function: protein binding |
UniProt Protein Details: | |
NCBI Summary: | |
UniProt Code: | Q3KR16 |
NCBI GenInfo Identifier: | 332278231 |
NCBI Gene ID: | 55200 |
NCBI Accession: | Q3KR16.3 |
UniProt Secondary Accession: | Q3KR16,Q3SWR1, Q8N1P1, Q8WYY1, Q9H8F4, Q9NVK9 |
UniProt Related Accession: | Q3KR16 |
Molecular Weight: | 35,568 Da |
NCBI Full Name: | Pleckstrin homology domain-containing family G member 6 |
NCBI Synonym Full Names: | pleckstrin homology and RhoGEF domain containing G6 |
NCBI Official Symbol: | PLEKHG6 |
NCBI Official Synonym Symbols: | MyoGEF |
NCBI Protein Information: | pleckstrin homology domain-containing family G member 6 |
UniProt Protein Name: | Pleckstrin homology domain-containing family G member 6 |
UniProt Synonym Protein Names: | Myosin-interacting guanine nucleotide exchange factor; MyoGEF |
Protein Family: | Pleckstrin homology domain-containing family |
UniProt Gene Name: | PLEKHG6 |
UniProt Entry Name: | PKHG6_HUMAN |