PLA2G4D Antibody (PACO03925)
- SKU:
- PACO03925
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PLA2G4D Antibody |
抗体コード: | PACO03925 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | IHC:1:100-1:300 |
反応性: | Human |
免疫原: | synthesized peptide derived from the Internal region of human cPLA2-delta. |
憲法: | Liquid |
ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | PLA2G4D; Cytosolic phospholipase A2 delta; cPLA2-delta; Phospholipase A2 group IVD |
UniProt Protein Function: | PLA2G4D: a calcium-dependent phospholipase A2 that catalyzes the release of arachidonic acid from membrane phospholipids. Selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions. Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues. Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin. The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca2+. Two isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.1.4; Phospholipase; Lipid Metabolism - arachidonic acid Chromosomal Location of Human Ortholog: 15q15.1 Cellular Component: cytosol Molecular Function:lysophospholipase activity; phospholipase A1 activity; phospholipase A2 activity Biological Process: phosphatidic acid biosynthetic process; phospholipid metabolic process |
NCBI Summary: | The phospholipase A2 enzyme family, including PLA2G4D, catalyze the hydrolysis of glycerophospholipids at the sn-2 position and then liberate free fatty acids and lysophospholipids (Chiba et al., 2004 [PubMed 14709560]).[supplied by OMIM, Jun 2009] |
UniProt Code: | Q86XP0 |
NCBI GenInfo Identifier: | 269849641 |
NCBI Gene ID: | 283748 |
NCBI Accession: | Q86XP0.2 |
UniProt Secondary Accession: | Q86XP0,Q8N176, |
UniProt Related Accession: | Q86XP0 |
Molecular Weight: | 80,930 Da |
NCBI Full Name: | Cytosolic phospholipase A2 delta |
NCBI Synonym Full Names: | phospholipase A2 group IVD |
NCBI Official Symbol: | PLA2G4D |
NCBI Official Synonym Symbols: | cPLA2delta |
NCBI Protein Information: | cytosolic phospholipase A2 delta |
UniProt Protein Name: | Cytosolic phospholipase A2 delta |
UniProt Synonym Protein Names: | Phospholipase A2 group IVD |
Protein Family: | Cytosolic phospholipase |
UniProt Gene Name: | PLA2G4D |
UniProt Entry Name: | PA24D_HUMAN |