PIP4K2A Antibody (PACO11253)
- SKU:
- PACO11253
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PIP4K2A Antibody (PACO11253) |
抗体コード: | PACO11253 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human PIP4K2A |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha;PIP4K2A;FLJ13267;PI5P4KA;PIP5K2A;PIP5KII-alpha;PIP5KIIA;PIPK ; |
UniProt Protein Function: | PIP4K2A: Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size. |
UniProt Protein Details: | Protein type:Kinase, lipid; EC 2.7.1.149; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate Chromosomal Location of Human Ortholog: 10p12.2 Cellular Component: plasma membrane; nucleus; cytosol Molecular Function:1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding Biological Process: phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process |
NCBI Summary: | Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008] |
UniProt Code: | P48426 |
NCBI GenInfo Identifier: | 18266879 |
NCBI Gene ID: | 5305 |
NCBI Accession: | P48426.2 |
UniProt Secondary Accession: | P48426,P53807, Q5VUX3, B0YJ66, B4DGX2, D3DRV1, |
UniProt Related Accession: | P48426 |
Molecular Weight: | 406 |
NCBI Full Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
NCBI Synonym Full Names: | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha |
NCBI Official Symbol: | PIP4K2A |
NCBI Official Synonym Symbols: | PIPK; PI5P4KA; PIP5K2A; PIP5KIIA; PIP5KII-alpha |
NCBI Protein Information: | phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; PIP5KIII; PIP5KIIalpha; PIP4KII-alpha; PI(5)P 4-kinase type II alpha; PtdIns(4)P-5-kinase B isoform; ptdIns(4)P-5-kinase C isoform; diphosphoinositide kinase 2-alpha; ptdIns(5)P-4-kinase isoform 2-alpha; 1-phosphatidylinositol-4-phosphate kinase; 1-phosphatidylinositol-4-phosphate-5-kinase; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; phosphatidylinositol 5-phosphate 4-kinase type II alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha; type II phosphatidylinositol-4-phosphate 5-kinase 53 K isoform |
UniProt Protein Name: | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha |
UniProt Synonym Protein Names: | 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; Diphosphoinositide kinase 2-alpha; PIP5KIII; Phosphatidylinositol 5-phosphate 4-kinase type II alpha; PI(5)P 4-kinase type II alpha; PIP4KII-alpha; PtdIns(4)P-5-kinase B isoform; PtdIns(4)P-5-kinase C isoform; PtdIns(5)P-4-kinase isoform 2-alpha |
Protein Family: | Phosphatidylinositol 5-phosphate 4-kinase |
UniProt Gene Name: | PIP4K2A |
UniProt Entry Name: | PI42A_HUMAN |