PIGM Antibody (PACO11239)
- SKU:
- PACO11239
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PIGM Antibody (PACO11239) |
抗体コード: | PACO11239 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human PIGM |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | phosphatidylinositol glycan anchor biosynthesis, class M;PIGM;GPI-MT-I;MGC29896 ; |
UniProt Protein Function: | PIGM: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Defects in PIGM are the cause of glycosylphosphatidylinositol deficiency (GPID). GPID is an autosomal recessive trait that results in a propensity to venous thrombosis and seizures. Deficiency is due to a point mutation in the regulatory sequences of PIGM that disrupts binding of the transcription factor SP1 to its cognate promoter motif, leading to a strong reduction of expression. Belongs to the PIGM family. |
UniProt Protein Details: | Protein type:Transferase; EC 2.4.1.-; Membrane protein, multi-pass; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.2 Cellular Component: endoplasmic reticulum membrane Biological Process: preassembly of GPI anchor in ER membrane Disease: Glycosylphosphatidylinositol Deficiency |
NCBI Summary: | This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9H3S5 |
NCBI GenInfo Identifier: | 74752622 |
NCBI Gene ID: | 93183 |
NCBI Accession: | Q9H3S5.1 |
UniProt Related Accession: | Q9H3S5 |
Molecular Weight: | 49,460 Da |
NCBI Full Name: | GPI mannosyltransferase 1 |
NCBI Synonym Full Names: | phosphatidylinositol glycan anchor biosynthesis class M |
NCBI Official Symbol: | PIGM |
NCBI Official Synonym Symbols: | GPI-MT-I |
NCBI Protein Information: | GPI mannosyltransferase 1 |
UniProt Protein Name: | GPI mannosyltransferase 1 |
UniProt Synonym Protein Names: | GPI mannosyltransferase I; GPI-MT-I; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M |
Protein Family: | Pigment-dispersing hormone |
UniProt Gene Name: | PIGM |
UniProt Entry Name: | PIGM_HUMAN |