Phospho-Map2k5 (Ser311/Thr315) Antibody (PACO23912)
- SKU:
- PACO23912
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 抗体名: | Phospho-Map2k5 (Ser311/Thr315) Antibody (PACO23912) |
| 抗体コード: | PACO23912 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Peptide sequence around phosphorylation site of Serine 311 and threonine 315 (V-N-S(p)I-A-K-T(p)-Y-V) derived from Rat MEK5. |
| 憲法: | Liquid |
| ストレージバッファ: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Rat and Mouse brain tissue using MEK5(phospho-Ser311/ Thr315) Antibody. |
| バックグラウンド: | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appear to play a critical role in protecting cells from stress-induced apopotosis, neuronal survival and cardiac development and angiogenesis. |
| シノニム: | Map2k5 |
| UniProt Protein Function: | MEK5: a dual specificity protein kinase of the STE7 family. Activates ERK5 and is itself phosphorylated and activated by MEKK3, as well as by atypical protein kinase C isoforms. Involved in growth factor stimulated cell proliferation and muscle cell differentiation. Four alternatively spliced isoforms have been described.Protein type: EC 2.7.12.2; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 familyCellular Component: membrane; spindle; intracellular; nucleus; cytosolMolecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; metal ion binding; protein-tyrosine kinase activity; ATP binding; protein kinase activityBiological Process: peptidyl-tyrosine phosphorylation; negative regulation of heterotypic cell-cell adhesion; activation of MAPK activity; heart development; MAPKKK cascade; negative regulation of interleukin-8 biosynthetic process; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; positive regulation of protein metabolic process; positive regulation of cell growth; inhibition of NF-kappaB transcription factor; positive regulation of transcription from RNA polymerase II promoter; positive regulation of epithelial cell proliferation |
| UniProt Protein Details: | |
| NCBI Summary: | kinase involved in signal transduction in the cell [RGD, Feb 2006] |
| UniProt Code: | Q62862 |
| NCBI GenInfo Identifier: | 2499634 |
| NCBI Gene ID: | 29568 |
| NCBI Accession: | Q62862.1 |
| UniProt Secondary Accession: | Q62862,Q62863, Q62864 |
| UniProt Related Accession: | Q62862 |
| Molecular Weight: | 448 |
| NCBI Full Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
| NCBI Synonym Full Names: | mitogen activated protein kinase kinase 5 |
| NCBI Official Symbol: | Map2k5 |
| NCBI Official Synonym Symbols: | Mek5 |
| NCBI Protein Information: | dual specificity mitogen-activated protein kinase kinase 5; MEK 5; MAPKK 5; MAPK/ERK kinase 5; MAP kinase kinase 5 |
| UniProt Protein Name: | Dual specificity mitogen-activated protein kinase kinase 5 |
| UniProt Synonym Protein Names: | MAPK/ERK kinase 5; MEK 5 |
| Protein Family: | Dual specificity mitogen-activated protein kinase kinase |
| UniProt Gene Name: | Map2k5 |
| UniProt Entry Name: | MP2K5_RAT |
Related Products
