Phospho-EIF2AK3 (Thr981) Antibody (PACO24119)
- SKU:
- PACO24119
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | Phospho-EIF2AK3 (Thr981) Antibody (PACO24119) |
抗体コード: | PACO24119 |
サイズ: | 100ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:50-1:100 |
反応性: | Human, Mouse |
免疫原: | Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK. |
憲法: | Liquid |
ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
精製方法: | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemical analysis of paraffin-embedded human prostate carcinoma tissue using PEK/PERK (Phospho-Thr982) antibody (left)or the same antibody preincubated with blocking peptide (right). |
バックグラウンド: | Phosphorylates the α subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) |
シノニム: | E2AK3; PERK; PEK; EIF2AK3; |
NCBI Summary: | The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Sep 2015] |
UniProt Code: | Q9NZJ5 |
NCBI GenInfo Identifier: | 296439367 |
NCBI Gene ID: | 9451 |
NCBI Accession: | |
UniProt Related Accession: | Q9NZJ5 |
Molecular Weight: | 170 |
NCBI Full Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
NCBI Synonym Full Names: | eukaryotic translation initiation factor 2 alpha kinase 3 |
NCBI Official Symbol: | EIF2AK3 |
NCBI Official Synonym Symbols: | PEK; WRS; PERK |
NCBI Protein Information: | eukaryotic translation initiation factor 2-alpha kinase 3 |
UniProt Protein Name: | |
UniProt Gene Name: |
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