PHF21A Antibody, HRP conjugated (PACO51807)
- SKU:
- PACO51807
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | PHF21A Antibody, HRP conjugated (PACO51807) |
抗体コード: | PACO51807 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human PHD finger protein 21A protein (312-487AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. |
シノニム: | PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80), PHF21A, BHC80 KIAA1696 |
UniProt Protein Function: | PHF21A: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: nucleoplasm; histone deacetylase complex Molecular Function:DNA binding; zinc ion binding; chromatin binding Biological Process: establishment and/or maintenance of chromatin architecture; suckling behavior; transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; blood coagulation |
NCBI Summary: | The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010] |
UniProt Code: | Q96BD5 |
NCBI GenInfo Identifier: | 74731224 |
NCBI Gene ID: | 51317 |
NCBI Accession: | Q96BD5.1 |
UniProt Secondary Accession: | Q96BD5,Q6AWA2, Q9C0G7, Q9H8V9, Q9HAK6, Q9NZE9, D3DQP5 |
UniProt Related Accession: | Q96BD5 |
Molecular Weight: | 680 |
NCBI Full Name: | PHD finger protein 21A |
NCBI Synonym Full Names: | PHD finger protein 21A |
NCBI Official Symbol: | PHF21A |
NCBI Official Synonym Symbols: | BHC80; BM-006 |
NCBI Protein Information: | PHD finger protein 21A; BHC80a; BRAF35/HDAC2 complex (80 kDa); BRAF35-HDAC complex protein BHC80 |
UniProt Protein Name: | PHD finger protein 21A |
UniProt Synonym Protein Names: | BHC80a; BRAF35-HDAC complex protein BHC80 |
Protein Family: | PHD finger protein |
UniProt Gene Name: | PHF21A |
UniProt Entry Name: | PF21A_HUMAN |