PGLYRP1 Antibody (PACO20218)
- SKU:
- PACO20218
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PGLYRP1 Antibody (PACO20218) |
抗体コード: | PACO20218 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human PGLYRP1 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-3: Hela cells, K562 cells, human fetal liver tissue, Primary antibody: PACO20218(PGLYRP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes. |
バックグラウンド: | Peptidoglycan recognition proteins (PGRPs) are molecules that recognize peptidoglycan, a large component in bacterial cell walls. In insects, PGRPs activate antimicrobial pathways, and in mammals PGRPs function as antibacterial neutrophil proteins. PGRP-L halts bacterial growth by acting as an alanine amidase, an enzyme that hydrolyzes the amide bond of bacterial peptidoglycan. PGRP-I and PGRP-I ∫ are also members of the PGRP family that help recognize bacteria by binding to peptidoglycan and Gram-positive bacteria, but they do not have amidase activity. PGRP-S participates in intracellular killing of Gram-positive bacteria by stimulating two antimicrobial defense systems, the prophenoloxidase cascade and the antimicrobial peptides through Toll receptors. |
シノニム: | peptidoglycan recognition protein 1 |
UniProt Protein Function: | PGLYRP1: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram- negative bacteria, and has bacteriostatic activity towards Gram- negative bacteria. Plays a role in innate immunity. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. |
UniProt Protein Details: | Protein type:Secreted, signal peptide; Apoptosis; Receptor, misc.; Secreted Chromosomal Location of Human Ortholog: 19q13.2-q13.3 Cellular Component: extracellular region Molecular Function:peptidoglycan receptor activity; peptidoglycan binding; zinc ion binding; N-acetylmuramoyl-L-alanine amidase activity Biological Process: defense response to Gram-positive bacterium; negative regulation of natural killer cell differentiation during immune response; detection of bacterium; negative regulation of interferon-gamma production; negative regulation of inflammatory response; innate immune response; immune response; pattern recognition receptor signaling pathway; peptidoglycan catabolic process |
UniProt Code: | O75594 |
NCBI GenInfo Identifier: | 18202143 |
NCBI Gene ID: | 8993 |
NCBI Accession: | O75594.1 |
UniProt Secondary Accession: | O75594,Q4VB36, |
UniProt Related Accession: | O75594 |
Molecular Weight: | |
NCBI Full Name: | Peptidoglycan recognition protein 1 |
NCBI Synonym Full Names: | peptidoglycan recognition protein 1 |
NCBI Official Symbol: | PGLYRP1 |
NCBI Official Synonym Symbols: | PGRP; TAG7; PGRPS; PGLYRP; PGRP-S; TNFSF3L |
NCBI Protein Information: | peptidoglycan recognition protein 1; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein) |
UniProt Protein Name: | Peptidoglycan recognition protein 1 |
UniProt Synonym Protein Names: | Peptidoglycan recognition protein short; PGRP-S |
Protein Family: | Peptidoglycan recognition protein |
UniProt Gene Name: | PGLYRP1 |
UniProt Entry Name: | PGRP1_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |