PFKL Antibody, HRP conjugated (PACO47587)
- SKU:
- PACO47587
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | PFKL Antibody, HRP conjugated (PACO47587) |
抗体コード: | PACO47587 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human ATP-dependent 6-phosphofructokinase, liver type protein (229-479AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. |
シノニム: | ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase), PFKL |
UniProt Protein Function: | PFKL: phosphofructokinase, liver type. An ubiquitous metabolic enzyme involved in the synthesis and degradation of fructose 2,6-bisphosphate. Key control step of glycolysis. An allosteric enzyme activated by ADP, AMP, or fructose bisphosphate and inhibited by ATP or citrate. Activity: ATP D-fructose 6-phosphate = ADP D-fructose 1,6-bisphosphate. The holoenzyme consists of 4 subunits. The liver and muscle enzymes are homo-tetramers of four liver or muscle isoforms, respectively. The red blood cell enzyme consists hetero-tetramers of the muscle and liver isoforms. A subunit composition with a higher proportion of platelet type subunits is found in platelets, brain and fibroblasts. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Kinase, other; EC 2.7.1.11; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: 6-phosphofructokinase complex; cytosol; membrane Molecular Function:6-phosphofructokinase activity; ATP binding; identical protein binding; kinase binding; protein binding Biological Process: fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; glycolysis; protein oligomerization; response to glucose stimulus |
NCBI Summary: | This gene encodes the liver (L) subunit of an enzyme that catalyzes the conversion of D-fructose 6-phosphate to D-fructose 1,6-bisphosphate, which is a key step in glucose metabolism (glycolysis). This enzyme is a tetramer that may be composed of different subunits encoded by distinct genes in different tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] |
UniProt Code: | P17858 |
NCBI GenInfo Identifier: | 134048493 |
NCBI Gene ID: | 5211 |
NCBI Accession: | P17858.6 |
UniProt Secondary Accession: | P17858,Q96A64, Q96IH4, Q9BR91, |
UniProt Related Accession: | P17858 |
Molecular Weight: | 90,203 Da |
NCBI Full Name: | ATP-dependent 6-phosphofructokinase, liver type |
NCBI Synonym Full Names: | phosphofructokinase, liver type |
NCBI Official Symbol: | PFKL |
NCBI Official Synonym Symbols: | PFK-B; PFK-L; ATP-PFK |
NCBI Protein Information: | ATP-dependent 6-phosphofructokinase, liver type |
UniProt Protein Name: | ATP-dependent 6-phosphofructokinase, liver type |
UniProt Synonym Protein Names: | 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B; PFK-B; Phosphohexokinase |
Protein Family: | ATP-dependent 6-phosphofructokinase |
UniProt Gene Name: | PFKL |
UniProt Entry Name: | PFKAL_HUMAN |