PES1 Antibody, FITC conjugated (PACO51800)
- SKU:
- PACO51800
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | PES1 Antibody, FITC conjugated (PACO51800) |
抗体コード: | PACO51800 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Pescadillo homolog protein (378-588AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. |
シノニム: | Pescadillo homolog, PES1 |
UniProt Protein Function: | PES1: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. Belongs to the pescadillo family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Translation; RNA-binding; Nucleolus Chromosomal Location of Human Ortholog: 22q12.1 Cellular Component: cytoplasm; membrane; nucleolus; nucleoplasm; nucleus Molecular Function:protein binding; RNA binding Biological Process: cell proliferation; maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); regulation of cell cycle; ribosomal large subunit biogenesis and assembly; rRNA processing |
NCBI Summary: | This gene encodes a nuclear protein that contains a breast cancer associated gene 1 (BRCA1) C-terminal interaction domain. The encoded protein interacts with BOP1 and WDR12 to form the PeBoW complex, which plays a critical role in cell proliferation via pre-rRNA processing and 60S ribosomal subunit maturation. Expression of this gene may play an important role in breast cancer proliferation and tumorigenicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Pseudogenes of this gene are located on the long arm of chromosome 4 and the short arm of chromosome 9. [provided by RefSeq, Aug 2011] |
UniProt Code: | O00541 |
NCBI GenInfo Identifier: | 21542165 |
NCBI Gene ID: | 23481 |
NCBI Accession: | O00541.1 |
UniProt Secondary Accession: | O00541,Q6IC29, |
UniProt Related Accession: | O00541 |
Molecular Weight: | 67,456 Da |
NCBI Full Name: | Pescadillo homolog |
NCBI Synonym Full Names: | pescadillo ribosomal biogenesis factor 1 |
NCBI Official Symbol: | PES1 |
NCBI Official Synonym Symbols: | PES |
NCBI Protein Information: | pescadillo homolog |
UniProt Protein Name: | Pescadillo homolog |
UniProt Gene Name: | PES1 |
UniProt Entry Name: | PESC_HUMAN |