PDP1 Antibody, FITC conjugated (PACO58546)
- SKU:
- PACO58546
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | PDP1 Antibody, FITC conjugated (PACO58546) |
抗体コード: | PACO58546 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial protein (1-154AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Catalyzes the dephosphorylation and concomitant reactivation of the α subunit of the E1 component of the pyruvate dehydrogenase complex. |
シノニム: | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP 1) (EC 3.1.3.43) (Protein phosphatase 2C) (Pyruvate dehydrogenase phosphatase catalytic subunit 1) (PDPC 1), PDP1, PDP PPM2C |
UniProt Protein Function: | PDP1: a protein phosphoserine phosphatase associated with the mitochondrial matrix that activates phosphorylated pyruvate dehydrogenase complex by dephosphorylation. The PDPs play crucial roles in switching metabolic flux from glycolysis towards oxidative phosphorylation. Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. PDP1 is composed of a catalytic subunit and a regulatory subunit (PDPR). Heterodimer of a catalytic subunit and a FAD protein of unknown function. Defects in PDP1 are the cause of pyruvate dehydrogenase phosphatase deficiency (PDP deficiency). PDP deficiency results in lactic acidosis leading to neurological dysfunction. Belongs to the PP2C family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.43; Mitochondrial; Protein phosphatase, Ser/Thr (non-receptor) Chromosomal Location of Human Ortholog: 8q22.1 Cellular Component: mitochondrial matrix Molecular Function:[pyruvate dehydrogenase (lipoamide)] phosphatase activity; protein binding; protein serine/threonine phosphatase activity Biological Process: regulation of acetyl-CoA biosynthetic process from pyruvate Disease: Pyruvate Dehydrogenase Phosphatase Deficiency |
NCBI Summary: | Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009] |
UniProt Code: | Q9P0J1 |
NCBI GenInfo Identifier: | 78099789 |
NCBI Gene ID: | 54704 |
NCBI Accession: | Q9P0J1.3 |
UniProt Secondary Accession: | Q9P0J1,Q5U5K1, B3KX71, J3KPU0, |
UniProt Related Accession: | Q9P0J1 |
Molecular Weight: | 63,695 Da |
NCBI Full Name: | [Pyruvate dehydrogenase |
NCBI Synonym Full Names: | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
NCBI Official Symbol: | PDP1 |
NCBI Official Synonym Symbols: | PDH; PDP; PDPC; PPM2A; PPM2C |
NCBI Protein Information: | pyruvate dehyrogenase phosphatase catalytic subunit 1 |
UniProt Protein Name: | [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial |
UniProt Synonym Protein Names: | Protein phosphatase 2C; Pyruvate dehydrogenase phosphatase catalytic subunit 1; PDPC 1 |
Protein Family: | PWWP domain-containing protein |
UniProt Gene Name: | PDP1 |
UniProt Entry Name: | PDP1_HUMAN |