UniProt Protein Function: | LIM: an adaptor protein of the Enigma family. Contains three LIM domains and one PDZ domain. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. Enigma family proteins possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 4q22 Cellular Component: postsynaptic membrane; neuron projection; membrane; postsynaptic density; cell junction; Z disc; cytosol; actin cytoskeleton Molecular Function:actinin binding; protein kinase C binding; zinc ion binding; protein N-terminus binding; actin binding Biological Process: regulation of synaptogenesis |
NCBI Summary: | This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
UniProt Code: | Q96HC4 |
NCBI GenInfo Identifier: | 317373590 |
NCBI Gene ID: | 10611 |
NCBI Accession: | Q96HC4.5 |
UniProt Secondary Accession: | Q96HC4,O60705, Q56VN4, Q5UW38, Q8WVK0, A8K6F9, D6RB78 E9PBF5, |
UniProt Related Accession: | Q96HC4 |
Molecular Weight: | 63,945 Da |
NCBI Full Name: | PDZ and LIM domain protein 5 |
NCBI Synonym Full Names: | PDZ and LIM domain 5 |
NCBI Official Symbol: | PDLIM5 |
NCBI Official Synonym Symbols: | L9; ENH; LIM; ENH1 |
NCBI Protein Information: | PDZ and LIM domain protein 5; enigma homolog; enigma-like LIM domain protein; enigma-like PDZ and LIM domains protein |
UniProt Protein Name: | PDZ and LIM domain protein 5 |
UniProt Synonym Protein Names: | Enigma homolog; Enigma-like PDZ and LIM domains protein |
UniProt Gene Name: | PDLIM5 |
UniProt Entry Name: | PDLI5_HUMAN |