PDE8A Antibody, Biotin conjugated (PACO63066)
- SKU:
- PACO63066
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | PDE8A Antibody, Biotin conjugated (PACO63066) |
抗体コード: | PACO63066 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A protein (596-829AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | Antigen Affinity Purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine. |
シノニム: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53), PDE8A |
UniProt Protein Function: | PDE8A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily. 5 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Chromosomal Location of Human Ortholog: 15q25.3 Cellular Component: cytosol Molecular Function:3',5'-cyclic-AMP phosphodiesterase activity; kinase binding Biological Process: positive regulation of protein amino acid phosphorylation |
NCBI Summary: | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011] |
UniProt Code: | O60658 |
NCBI GenInfo Identifier: | 23503044 |
NCBI Gene ID: | 5151 |
NCBI Accession: | O60658.2 |
UniProt Secondary Accession: | O60658,Q6P9H3, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q96T71 Q9UMB7, Q9UMC3, B3KXE6, H0YMZ7, |
UniProt Related Accession: | O60658 |
Molecular Weight: | 93kDa |
NCBI Full Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
NCBI Synonym Full Names: | phosphodiesterase 8A |
NCBI Official Symbol: | PDE8A |
NCBI Official Synonym Symbols: | HsT19550 |
NCBI Protein Information: | high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
UniProt Protein Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
Protein Family: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase |
UniProt Gene Name: | PDE8A |