PDCD4 Antibody (PACO01307)
- SKU:
- PACO01307
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 抗体名: | PDCD4 Antibody |
| 抗体コード: | PACO01307 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from human Pdcd-4 around the non-phosphorylation site of S457. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | PDCD4; H731; Programmed cell death protein 4; Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a |
| UniProt Protein Function: | PDCD4: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified. |
| UniProt Protein Details: | Protein type:Tumor suppressor; Apoptosis Chromosomal Location of Human Ortholog: 10q24 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; RNA binding Biological Process: apoptosis; cell aging; negative regulation of apoptosis; negative regulation of cell cycle; negative regulation of JNK activity; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q53EL6 |
| NCBI GenInfo Identifier: | 317373317 |
| NCBI Gene ID: | 27250 |
| NCBI Accession: | Q53EL6.2 |
| UniProt Secondary Accession: | Q53EL6,O15501, Q5VZS6, Q6PJI5, Q8TAR5, Q99834, B2RCV4 B5ME91, |
| UniProt Related Accession: | Q53EL6 |
| Molecular Weight: | 50,576 Da |
| NCBI Full Name: | Programmed cell death protein 4 |
| NCBI Synonym Full Names: | programmed cell death 4 (neoplastic transformation inhibitor) |
| NCBI Official Symbol: | PDCD4 |
| NCBI Official Synonym Symbols: | H731 |
| NCBI Protein Information: | programmed cell death protein 4 |
| UniProt Protein Name: | Programmed cell death protein 4 |
| UniProt Synonym Protein Names: | Neoplastic transformation inhibitor protein; Nuclear antigen H731-like; Protein 197/15a |
| Protein Family: | Programmed cell death protein |
| UniProt Gene Name: | PDCD4 |
| UniProt Entry Name: | PDCD4_HUMAN |