PCCA Antibody (PACO51782)
- SKU:
- PACO51782
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PCCA Antibody (PACO51782) |
抗体コード: | PACO51782 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB, IHC |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200 |
反応性: | Human, Mouse |
免疫原: | Recombinant Human Propionyl-CoA carboxylase α chain, mitochondrial protein (585-720AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: NIH/3T3 whole cell lysate, Hela whole cell lysate. All lanes: PCCA antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 81, 78, 76 kDa. Observed band size: 81 kDa.. |
![]() | Immunohistochemistry of paraffin-embedded human heart tissue using PACO51782 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human liver tissue using PACO51782 at dilution of 1:100. |
バックグラウンド: | cytosol, mitochondrial matrix, biotin binding, enzyme binding, propionyl-CoA carboxylase activity, biotin metabolic process, short-chain fatty acid, catabolic process |
シノニム: | Propionyl-CoA carboxylase α chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha), PCCA |
UniProt Protein Function: | PCCA: Defects in PCCA are the cause of propionic acidemia type I (PA-1). PA-1 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - propanoate; Ligase; Mitochondrial; EC 6.4.1.3; Amino Acid Metabolism - valine, leucine and isoleucine degradation Chromosomal Location of Human Ortholog: 13q32 Cellular Component: cytosol; mitochondrial matrix Molecular Function:biotin binding; enzyme binding Biological Process: biotin metabolic process; short-chain fatty acid catabolic process Disease: Propionic Acidemia |
NCBI Summary: | The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010] |
UniProt Code: | P05165 |
NCBI GenInfo Identifier: | 308153661 |
NCBI Gene ID: | 5095 |
NCBI Accession: | P05165.4 |
UniProt Secondary Accession: | P05165,Q15979, Q8WXQ7, B4DKY8, B4DPF9, C9JPQ8, |
UniProt Related Accession: | P05165 |
Molecular Weight: | 75,002 Da |
NCBI Full Name: | Propionyl-CoA carboxylase alpha chain, mitochondrial |
NCBI Synonym Full Names: | propionyl-CoA carboxylase alpha subunit |
NCBI Official Symbol: | PCCA |
NCBI Protein Information: | propionyl-CoA carboxylase alpha chain, mitochondrial |
UniProt Protein Name: | Propionyl-CoA carboxylase alpha chain, mitochondrial |
UniProt Synonym Protein Names: | Propanoyl-CoA:carbon dioxide ligase subunit alpha |
UniProt Gene Name: | PCCA |
UniProt Entry Name: | PCCA_HUMAN |
Antibodies |
Anti-PCCA Antibody (CAB9486) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |