PAM Antibody, FITC conjugated (PACO56914)
- SKU:
- PACO56914
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- FITC
Frequently bought together:
Description
抗体名: | PAM Antibody, FITC conjugated (PACO56914) |
抗体コード: | PACO56914 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Peptidyl-glycine alpha-amidating monooxygenase protein (338-497AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | FITC |
バックグラウンド: | Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. |
シノニム: | Peptidyl-glycine alpha-amidating monooxygenase (PAM) [Includes: Peptidylglycine alpha-hydroxylating monooxygenase (PHM) (EC 1.14.17.3); Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC 4.3.2.5) (Peptidylamidoglycolate lyase) (PAL)], PAM |
UniProt Protein Function: | Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity. |
NCBI Summary: | This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016] |
UniProt Code: | P19021 |
NCBI GenInfo Identifier: | 21070984 |
NCBI Gene ID: | 5066 |
NCBI Accession: | NP_000910.2 |
UniProt Related Accession: | P19021 |
Molecular Weight: | 36kDa |
NCBI Full Name: | peptidyl-glycine alpha-amidating monooxygenase isoform a |
NCBI Synonym Full Names: | peptidylglycine alpha-amidating monooxygenase |
NCBI Official Symbol: | PAM |
NCBI Official Synonym Symbols: | PAL; PHM |
NCBI Protein Information: | peptidyl-glycine alpha-amidating monooxygenase |
UniProt Protein Name: | Peptidyl-glycine alpha-amidating monooxygenase |
UniProt Synonym Protein Names: | Peptidylglycine alpha-hydroxylating monooxygenase (EC:1.14.17.3); PHMPeptidyl-alpha-hydroxyglycine alpha-amidating lyase (EC:4.3.2.5)Alternative name(s):Peptidylamidoglycolate lyase; PAL |
Protein Family: | Phenylalanine aminomutase |
UniProt Gene Name: | PAM |