PACSIN3 Antibody (PACO54594)
- SKU:
- PACO54594
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | PACSIN3 Antibody (PACO54594) |
抗体コード: | PACO54594 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
反応性: | Human |
免疫原: | Recombinant Human Protein kinase C and casein kinase substrate in neurons protein 3 protein (1-300AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, HEK293 whole cell lysate. All lanes: PACSIN3 antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 49 kDa. Observed band size: 49 kDa. |
バックグラウンド: | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). |
シノニム: | Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511), PACSIN3 |
UniProt Protein Function: | PACSIN3: May play a role in vesicle formation and transport. Belongs to the PACSIN family. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Vesicle Chromosomal Location of Human Ortholog: 11p12-p11.12 Cellular Component: cytoplasm; endosome; nucleoplasm; plasma membrane Molecular Function:calcium channel inhibitor activity; cytoskeletal protein binding; lipid binding; protein binding Biological Process: negative regulation of calcium ion transport; negative regulation of endocytosis; positive regulation of membrane protein ectodomain proteolysis; regulation of endocytosis |
NCBI Summary: | This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
UniProt Code: | Q9UKS6 |
NCBI GenInfo Identifier: | 22256967 |
NCBI Gene ID: | 29763 |
NCBI Accession: | Q9UKS6.2 |
UniProt Secondary Accession: | Q9UKS6,Q9H331, Q9NWV9, A6NH84, |
UniProt Related Accession: | Q9UKS6 |
Molecular Weight: | 48,487 Da |
NCBI Full Name: | Protein kinase C and casein kinase substrate in neurons protein 3 |
NCBI Synonym Full Names: | protein kinase C and casein kinase substrate in neurons 3 |
NCBI Official Symbol: | PACSIN3 |
NCBI Official Synonym Symbols: | SDPIII |
NCBI Protein Information: | protein kinase C and casein kinase substrate in neurons protein 3 |
UniProt Protein Name: | Protein kinase C and casein kinase substrate in neurons protein 3 |
UniProt Synonym Protein Names: | SH3 domain-containing protein 6511 |
Protein Family: | Protein kinase C and casein kinase II substrate protein |
UniProt Gene Name: | PACSIN3 |
UniProt Entry Name: | PACN3_HUMAN |