P2RY2 Antibody (PACO20153)
- SKU:
- PACO20153
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | P2RY2 Antibody (PACO20153) |
抗体コード: | PACO20153 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, IHC |
推奨される希釈: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
反応性: | Human, Mouse, Rat |
免疫原: | Synthetic peptide of human P2RY2 |
憲法: | Liquid |
ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
精製方法: | Antigen affinity purification |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20153(P2RY2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). | |
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20153(P2RY2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
バックグラウンド: | The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. |
シノニム: | purinergic receptor P2Y, G-protein coupled, 2 |
UniProt Protein Function: | P2Y2: a G-protein coupled receptor of the rhodopsin family. This family includes hormone, neurotransmitter and light receptors. Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP. May participate in control of the cell cycle and proliferation. |
UniProt Protein Details: | Protein type:Receptor, GPCR; Membrane protein, multi-pass; Receptor, misc.; GPCR, family 1; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q13.5-q14.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:purinergic nucleotide receptor activity, G-protein coupled; receptor activity Biological Process: regulation of vasodilation; cellular ion homeostasis; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) |
NCBI Summary: | The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013] |
UniProt Code: | P41231 |
NCBI GenInfo Identifier: | 311033490 |
NCBI Gene ID: | 5029 |
NCBI Accession: | P41231.4 |
UniProt Secondary Accession: | P41231,Q96EM8, B2R9W3, |
UniProt Related Accession: | P41231 |
Molecular Weight: | 377 |
NCBI Full Name: | P2Y purinoceptor 2 |
NCBI Synonym Full Names: | purinergic receptor P2Y, G-protein coupled, 2 |
NCBI Official Symbol: | P2RY2 |
NCBI Official Synonym Symbols: | P2U; HP2U; P2U1; P2UR; P2Y2; P2RU1; P2Y2R |
NCBI Protein Information: | P2Y purinoceptor 2; ATP receptor; P2U receptor 1; purinoceptor P2Y2; P2U purinoceptor 1; P2U nucleotide receptor; purinergic receptor P2Y2 |
UniProt Protein Name: | P2Y purinoceptor 2 |
UniProt Synonym Protein Names: | ATP receptor; P2U purinoceptor 1; P2U1; P2U receptor 1; Purinergic receptor |
Protein Family: | P2Y purinoceptor |
UniProt Gene Name: | P2RY2 |
UniProt Entry Name: | P2RY2_HUMAN |