OTUD7B Antibody, HRP conjugated (PACO58209)
- SKU:
- PACO58209
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | OTUD7B Antibody, HRP conjugated (PACO58209) |
抗体コード: | PACO58209 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human OTU domain-containing protein 7B protein (235-347AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B. Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR. Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure. Hydrolyzes both linear and branched forms of polyubiquitin. |
シノニム: | OTU domain-containing protein 7B (EC 3.4.19.12) (Cellular zinc finger anti-NF-kappa-B protein) (Cezanne) (Zinc finger A20 domain-containing protein 1) (Zinc finger protein Cezanne), OTUD7B, ZA20D1 |
UniProt Protein Function: | Cezanne: cellular zinc finger anti-NF-kappaB, a negative regulator of NF-kappaB. A novel deubiquitinating enzyme that belongs to the ovarian tumor protein (OTU) superfamily. |
UniProt Protein Details: | Protein type:EC 3.4.19.12; Ubiquitin conjugating system; Protease Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; DNA binding; zinc ion binding; ubiquitin-specific protease activity; cysteine-type peptidase activity Biological Process: mucosal immune response; negative regulation of interleukin-8 production; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; proteolysis |
UniProt Code: | Q6GQQ9 |
NCBI GenInfo Identifier: | 51701318 |
NCBI Gene ID: | 56957 |
NCBI Accession: | Q6GQQ9.1 |
UniProt Related Accession: | Q6GQQ9 |
Molecular Weight: | |
NCBI Full Name: | OTU domain-containing protein 7B |
NCBI Synonym Full Names: | OTU deubiquitinase 7B |
NCBI Official Symbol: | OTUD7B |
NCBI Official Synonym Symbols: | ZA20D1; CEZANNE |
NCBI Protein Information: | OTU domain-containing protein 7B |
UniProt Protein Name: | OTU domain-containing protein 7B |
UniProt Synonym Protein Names: | Cellular zinc finger anti-NF-kappa-B protein; Zinc finger A20 domain-containing protein 1; Zinc finger protein Cezanne |
UniProt Gene Name: | OTUD7B |
UniProt Entry Name: | OTU7B_HUMAN |