OSBP Antibody, HRP conjugated (PACO62328)
- SKU:
- PACO62328
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- HRP
Frequently bought together:
Description
抗体名: | OSBP Antibody, HRP conjugated (PACO62328) |
抗体コード: | PACO62328 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Oxysterol-binding protein 1 protein (628-802AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | HRP |
バックグラウンド: | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. |
シノニム: | Oxysterol-binding protein 1, OSBP, OSBP1 |
UniProt Protein Function: | OSBP: Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. Belongs to the OSBP family. |
UniProt Protein Details: | Protein type:Lipid-binding Chromosomal Location of Human Ortholog: 11q12-q13 Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; cytoplasm; nucleolus; nucleus; cell junction Molecular Function:protein domain specific binding; protein binding; oxysterol binding Biological Process: lipid transport |
NCBI Summary: | Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008] |
UniProt Code: | P22059 |
NCBI GenInfo Identifier: | 129308 |
NCBI Gene ID: | 5007 |
NCBI Accession: | P22059.1 |
UniProt Secondary Accession: | P22059,Q6P524, |
UniProt Related Accession: | P22059 |
Molecular Weight: | 807 |
NCBI Full Name: | Oxysterol-binding protein 1 |
NCBI Synonym Full Names: | oxysterol binding protein |
NCBI Official Symbol: | OSBP |
NCBI Official Synonym Symbols: | OSBP1 |
NCBI Protein Information: | oxysterol-binding protein 1 |
UniProt Protein Name: | Oxysterol-binding protein 1 |
Protein Family: | Oxysterol-binding protein |
UniProt Gene Name: | OSBP |
UniProt Entry Name: | OSBP1_HUMAN |