ORC6 Antibody (PACO11015)
- SKU:
- PACO11015
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | ORC6 Antibody (PACO11015) |
抗体コード: | PACO11015 |
サイズ: | 50ul |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | |
反応性: | Human, Mouse, Rat |
免疫原: | Human ORC6L |
憲法: | Liquid |
ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
精製方法: | Antigen Affinity purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
シノニム: | origin recognition complex, subunit 6 like (yeast);ORC6L;ORC6 ; |
UniProt Protein Function: | ORC6L: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. ORC is composed of six subunits. In human, ORC is cell cycle-dependent regulated: it is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with DBF4. Belongs to the ORC6 family. |
UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 16q12 Cellular Component: nucleoplasm; membrane; plasma membrane; nuclear origin of replication recognition complex; nucleus; origin recognition complex Molecular Function:protein binding; DNA binding Biological Process: mitotic cell cycle; DNA replication; DNA-dependent DNA replication; G1/S transition of mitotic cell cycle Disease: Meier-gorlin Syndrome 3 |
NCBI Summary: | The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010] |
UniProt Code: | Q9Y5N6 |
NCBI GenInfo Identifier: | 8928274 |
NCBI Gene ID: | 23594 |
NCBI Accession: | Q9Y5N6.1 |
UniProt Secondary Accession: | Q9Y5N6,B3KN89, |
UniProt Related Accession: | Q9Y5N6 |
Molecular Weight: | 252 |
NCBI Full Name: | Origin recognition complex subunit 6 |
NCBI Synonym Full Names: | origin recognition complex, subunit 6 |
NCBI Official Symbol: | ORC6 |
NCBI Official Synonym Symbols: | ORC6L |
NCBI Protein Information: | origin recognition complex subunit 6 |
UniProt Protein Name: | Origin recognition complex subunit 6 |
Protein Family: | Origin recognition complex |
UniProt Gene Name: | ORC6 |
UniProt Entry Name: | ORC6_HUMAN |