ORAI1 Antibody, Biotin conjugated (PACO54169)
- SKU:
- PACO54169
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | ORAI1 Antibody, Biotin conjugated (PACO54169) |
抗体コード: | PACO54169 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Calcium release-activated calcium channel protein 1 protein (1-87AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. |
シノニム: | Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A), ORAI1, CRACM1 TMEM142A |
UniProt Protein Function: | ORAI1: Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. Interacts with STIM1 and STIM2. Interacts with EFCAB4B/CRACR2A; the interaction is direct and takes place in absence of Ca(2+). Forms a complex with EFCAB4B/CRACR2A and STIM1 at low concentration of Ca(2+), the complex dissociates at elevated Ca(2+) concentrations. Belongs to the Orai family. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium Chromosomal Location of Human Ortholog: 12q24.31 Cellular Component: protein complex; membrane; integral to plasma membrane Molecular Function:calmodulin binding; identical protein binding; protein binding; store-operated calcium channel activity Biological Process: immune system process; regulation of calcium ion transport; positive regulation of calcium ion transport; blood coagulation Disease: Myopathy, Tubular Aggregate, 2; Immunodeficiency 9 |
NCBI Summary: | The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] |
UniProt Code: | Q96D31 |
NCBI GenInfo Identifier: | 97180269 |
NCBI Gene ID: | 84876 |
NCBI Accession: | Q96D31.2 |
UniProt Secondary Accession: | Q96D31,Q5M848, Q8BWG9, Q6TLE6, Q5ZL05, |
UniProt Related Accession: | Q96D31 |
Molecular Weight: | 25,337 Da |
NCBI Full Name: | Calcium release-activated calcium channel protein 1 |
NCBI Synonym Full Names: | ORAI calcium release-activated calcium modulator 1 |
NCBI Official Symbol: | ORAI1 |
NCBI Official Synonym Symbols: | IMD9; TAM2; ORAT1; CRACM1; TMEM142A |
NCBI Protein Information: | calcium release-activated calcium channel protein 1; protein orai-1; transmembrane protein 142A; calcium release-activated calcium modulator 1 |
UniProt Protein Name: | Calcium release-activated calcium channel protein 1 |
UniProt Synonym Protein Names: | Protein orai-1; Transmembrane protein 142A |
UniProt Gene Name: | ORAI1 |
UniProt Entry Name: | CRCM1_HUMAN |