OMA1 Antibody, Biotin conjugated (PACO40113)
- SKU:
- PACO40113
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Biotin
Frequently bought together:
Description
抗体名: | OMA1 Antibody, Biotin conjugated (PACO40113) |
抗体コード: | PACO40113 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA |
推奨される希釈: | |
反応性: | Human |
免疫原: | Recombinant Human Metalloendopeptidase OMA1, mitochondrial protein (22-194AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Biotin |
バックグラウンド: | Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. |
シノニム: | Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Metalloprotease-related protein 1) (MPRP-1) (Overlapping with the m-AAA protease 1 homolog), OMA1, MPRP1 |
UniProt Protein Function: | OMA1: Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase M48 family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Protease; Membrane protein, multi-pass; Membrane protein, integral; EC 3.4.24.- Chromosomal Location of Human Ortholog: 1p32.2-p32.1 Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrial membrane Molecular Function:metal ion binding; metalloendopeptidase activity Biological Process: cristae formation; diet induced thermogenesis; glucose metabolic process; lipid metabolic process; misfolded or incompletely synthesized protein catabolic process; response to stress |
UniProt Code: | Q96E52 |
NCBI GenInfo Identifier: | 21686999 |
NCBI Gene ID: | 115209 |
NCBI Accession: | NP_660286.1 |
UniProt Secondary Accession: | Q96E52,Q5T3G6, Q5T3G7, Q5T3G8, Q5T3G9, Q5T3H0, Q8NBB3 D3DQ54, |
UniProt Related Accession: | Q96E52 |
Molecular Weight: | 55,744 Da |
NCBI Full Name: | metalloendopeptidase OMA1, mitochondrial |
NCBI Synonym Full Names: | OMA1 zinc metallopeptidase |
NCBI Official Symbol: | OMA1 |
NCBI Official Synonym Symbols: | DAB1; MPRP-1; YKR087C; ZMPOMA1; peptidase; 2010001O09Rik |
NCBI Protein Information: | metalloendopeptidase OMA1, mitochondrial |
UniProt Protein Name: | Metalloendopeptidase OMA1, mitochondrial |
UniProt Synonym Protein Names: | Metalloprotease-related protein 1; MPRP-1; Overlapping with the m-AAA protease 1 homolog |
Protein Family: | Metalloendopeptidase |
UniProt Gene Name: | OMA1 |
UniProt Entry Name: | OMA1_HUMAN |