OCRL Antibody (PACO55702)
- SKU:
- PACO55702
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| 抗体名: | OCRL Antibody (PACO55702) |
| 抗体コード: | PACO55702 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Inositol polyphosphate 5-phosphatase OCRL-1 protein (121-271AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO55702 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO55702 diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| バックグラウンド: | Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly. |
| シノニム: | Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein), OCRL, INPP5F OCRL1 |
| UniProt Protein Function: | Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate (PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly (PubMed:22228094, PubMed:22543976). |
| NCBI Summary: | This gene encodes an inositol polyphosphate 5-phosphatase. This protein is involved in regulating membrane trafficking and is located in numerous subcellular locations including the trans-Golgi network, clathrin-coated vesicles and, endosomes and the plasma membrane. This protein may also play a role in primary cilium formation. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q01968 |
| NCBI GenInfo Identifier: | 13325072 |
| NCBI Gene ID: | 4952 |
| NCBI Accession: | NP_000267.2 |
| UniProt Related Accession: | Q01968 |
| Molecular Weight: | |
| NCBI Full Name: | inositol polyphosphate 5-phosphatase OCRL isoform a |
| NCBI Synonym Full Names: | OCRL inositol polyphosphate-5-phosphatase |
| NCBI Official Symbol: | OCRL |
| NCBI Official Synonym Symbols: | LOCR; NPHL2; OCRL1; Dent-2; INPP5F; OCRL-1 |
| NCBI Protein Information: | inositol polyphosphate 5-phosphatase OCRL |
| UniProt Protein Name: | Inositol polyphosphate 5-phosphatase OCRL-1 |
| UniProt Synonym Protein Names: | Lowe oculocerebrorenal syndrome protein |
| Protein Family: | Inositol polyphosphate 5-phosphatase |
| UniProt Gene Name: | OCRL |
| Antibodies |
| Anti-OCRL Antibody (CAB9290) |
| Anti-OCRL Antibody (CAB19976)[KO Validated] |
| OCRL Antibody (PACO01195) |
| OCRL Antibody (PACO10991) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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