OCA2 Antibody (PACO57060)
- SKU:
- PACO57060
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
抗体名: | OCA2 Antibody (PACO57060) |
抗体コード: | PACO57060 |
サイズ: | 50ug |
宿主種: | Rabbit |
申し込み: | ELISA, WB |
推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
反応性: | Human, Rat |
免疫原: | Recombinant Human P protein (2-136AA) |
憲法: | Liquid |
ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
精製方法: | >95%, Protein G purified |
抗体のクローン性: | Polyclonal |
アイソタイプ: | IgG |
Conjugate: | Non-conjugated |
Western Blot. Positive WB detected in: K562 whole cell lysate, 293T whole cell lysate, A549 whole cell lysate, U87 whole cell lysate, HL60 whole cell lysate, Rat brain tissue. All lanes: OCA2 antibody at 8.93µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 93, 91, 75 kDa. Observed band size: 93 kDa. |
バックグラウンド: | Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. |
シノニム: | P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog), OCA2, D15S12 P |
UniProt Protein Function: | OCA2: a transporer of tyrosine, a precursor for melanin synthesis, within melanocytes. Regulates the pH of melanosomes and melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. Belongs to the SLC13A transporter family. |
UniProt Protein Details: | Protein type:Transporter; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q Cellular Component: endoplasmic reticulum membrane; lysosomal membrane; cytoplasm; melanosome membrane; integral to membrane; endosome membrane Molecular Function:protein binding; transporter activity; L-tyrosine transmembrane transporter activity Biological Process: melanin biosynthetic process; cell proliferation; tyrosine transport; melanocyte differentiation; transmembrane transport; eye pigment biosynthetic process; spermatid development Disease: Albinism, Oculocutaneous, Type Ii; Skin/hair/eye Pigmentation, Variation In, 1 |
NCBI Summary: | This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
UniProt Code: | Q04671 |
NCBI GenInfo Identifier: | 90110050 |
NCBI Gene ID: | 4948 |
NCBI Accession: | Q04671.2 |
UniProt Secondary Accession: | Q04671,Q15211, Q15212, Q96EN1, Q9UMI5, |
UniProt Related Accession: | Q04671 |
Molecular Weight: | 838 |
NCBI Full Name: | P protein |
NCBI Synonym Full Names: | oculocutaneous albinism II |
NCBI Official Symbol: | OCA2 |
NCBI Official Synonym Symbols: | P; BEY; PED; BEY1; BEY2; BOCA; EYCL; HCL3; EYCL2; EYCL3; SHEP1; D15S12 |
NCBI Protein Information: | P protein; P-protein; eye color 3 (brown); hair color 3 (brown); eye color 2 (central brown); total brown iris pigmentation; pink-eyed dilution protein homolog; melanocyte-specific transporter protein; oculocutaneous albinism II (pink-eye dilution homolog, mouse) |
UniProt Protein Name: | P protein |
UniProt Synonym Protein Names: | Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog |
Protein Family: | P protein |
UniProt Gene Name: | OCA2 |
UniProt Entry Name: | P_HUMAN |
Antibodies |
Anti-OCA2 Antibody (CAB5653) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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